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Optimization and extensions of the nucleophile catalyzed aldol-lactonization (NCAL) process for bicyclic beta-lactone synthesis: applications to piperidine, pyrrolidine, and gamma-lactam-fused beta-lactonesOh, Seongho 16 August 2006 (has links)
The intramolecular nucleophile catalyzed aldol-lactonization (NCAL) process
was optimized successfully. A variety of C9-acylated cinchona alkaloids were
synthesized and used for NCAL reactions with non-activated aldehydes. New
pyridinium salts, derivatives of MukaiyamaÂs reagent, led to marked improvements in
efficiency for the catalytic, asymmetric NCAL process while maintaining high
enantioselectivity. Larger scale versions of the catalytic, asymmetric NCAL reaction
were also developed allowing practical access to chiral bicyclic b-lactones. As an
extension of the intramolecular NCAL process, pyrrolidine and piperidine fused blactones
were synthesized. Simple g-lactam fused b-lactones were synthesized as a
model study for omuralide, salinosporamide A, and derivative synthesis. Synthesis of asubstituted
aldehyde acids was extensively studied but steric effects from both acid and
amine moieties led to great difficulties in this approach.
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Synthesis of atropisomeric 1-Naphthamide-Derived phosphines and application for asymmetric heck and Suzuki-Miyaura reactions /Sun, Lijie. January 2009 (has links)
Includes bibliographical references (p. 176-187).
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X-ray crystal structures of inhibited bovine pancreatic trypsinBertrand, Jay Aaron 08 1900 (has links)
No description available.
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Approaches to the asymmetric synthesis of 2-arylpropanoic acids / by Josephine Louise Newton.Newton, Josephine Louise January 1995 (has links)
Bibliography : leaves 200-206. / iv, 206 leaves ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Covers the asymmetric synthesis of 2-arylpropanoic acids including ketoprofen, ibuprofen, ximoprofen. / Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 1995
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Synthesis and reactions of a non-racemic, bicyclic chiral auxiliary / by Jeffrey William Holman.Holman, Jeffrey William January 1992 (has links)
Bibliography: leaves 213-218. / v, 218 leaves ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Organic Chemistry, 1993
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The asymmetric synthesis of polyfunctional pyrrolidine alkaloids and their analoguesLindsay, Karl B. January 2003 (has links)
Thesis (Ph.D.)--University of Wollongong, 2003. / Typescript. Includes bibliographical references: leaf 214-222.
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Studies on the optimization of catalytic asymmetric aziridination reaction tactics and mechanism /Lu, Zhenjie. January 2008 (has links)
Thesis (Ph. D.)--Michigan State University. Dept. of Chemistry, 2008. / Title from PDF t.p. (viewed on Mar. 30, 2009) Includes bibliographical references (p. 375-386). Also issued in print.
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The asymmetric synthesis of polyhydroxylated pyrrolizidine alkaloidsTang, Minyan. January 2004 (has links)
Thesis (Ph.D.)--University of Wollongong, 2004. / Typescript. Includes bibliographical references: leaf 236-249.
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De novo asymmetric synthesis of digitoxin based carbohydrate librariesXin, Wenjun. January 1900 (has links)
Thesis (M.S.)--West Virginia University, 2007. / Title from document title page. Document formatted into pages; contains x, 67 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 37-38).
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The use of chiro-inositols in asymmetric synthesisSingleton, Jamie Andrew. January 2008 (has links)
Thesis (Ph.D.)--University of Wyoming, 2008. / Title from PDF title page (viewed on August 3, 2009). Includes bibliographical references (p. 125-129).
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