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Thesis (Ph. D.)--University of Wisconsin--Madison, 1955. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 83-93).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1952. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 99-115).

Part of a current research program undertaken by the faculty in chemistry at the College of the Pacific is concerned with studying chemical compounds which are favorably absorbed in Aureomycin. The reason for this preference of absorption is still not known. In order to determine the cause of this absorption, it is necessary to establish a method of recovering tetracycline and its derivatives from malignant tissue. When working with recovery of tetracycline and its derivatives, the small scale of operations immediately suggests the use of chromatographic techniques of separation, identification, and estimation.

Typescript (photocopy). / Digitized by Kansas Correctional Industries

Importance of project: In recent years many antibiotics have come to the foreground as a treatment for mastitis. Aureomycin is one of the more recent antibiotics that has been used for this purpose. Aureomycin has been reported to be successful in curing some types of mastitis, but milk produced by cows that have been treated with Aureomycin does not act normal in the cheese manufacturing process. The most noticeable effect in milk from cows treated with Aureomycin has been slow or complete cessation of acid production by bacteria in cultured dairy products; this has been especially true in the cheese manufacturing process. In the even of slow acid production, or complete cessation of acid production, the cheese produced is either of lower quality than would normally be exected, or the entire vat of cheese may be lost. In either case there is a definite advers effect on the dairy industry. Purpose of investigation: The purpose of this problem is to determine the percentage of Aureomycin necessary in milk to cause slow or complete cessation of acid production in the cheese manufacturing process, and to find a chemical or heat treatment that can be used to inactivate the aureomycin so that there will be no harmful effect in milk used to manufacture cheese.