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Additive Manufacturing for Robust and Affordable Medical DevicesWolozny Gomez Robelo, Daniel Andre 18 October 2016 (has links)
Additive manufacturing in the form of 3D printing is a revolutionary technology that has developed within the last two decades. Its ability to print an object with accurate features down to the micro scale have made its use in medical devices and research feasible. A range of life-saving technologies can now go from the laboratory and into field with the application of 3D-printing.
This technology can be applied to medical diagnosis of patients in at-risk populations. Living biosensors are limited by being Genetically Modified Organisms (GMOs) from being employed for medical diagnosis. However, by containing them within a 3D-printed enclosure, these technologies can serve as a vehicle to translate life-saving diagnosis technologies from the laboratory and into the field where the lower cost would allow more people to benefit from inexpensive diagnosis. Also, the GMO biosensors would be contained with a press-fit, ensuring that the living biosensors are unable to escape into the environment without user input.
In addition, 3D-printing can also be applied to reduce the cost of lab-based technologies. Cell patterning technology is a target of interest for applying more cost-effective technologies, as elucidation of the variables defining cell patterning and motility may help explain the mechanics of cancer and other diseases. Through the use of a 3D-printed stamp, bacterial cells can be patterning without the use of a clean room, thus lowering the entry-barrier for researchers to explore cell patterning.
With the commercialization of 3D-printing an opportunity has arisen to transition life-saving technologies into more cost-effective versions of existing technologies. This would not only allow more research into existing fields, but also to ensure that potentially life-saving technologies reach the people that need them. / Ph. D. / 3D-printing is a revolutionary technology developed within the last two decades. Its ability to print an object with accurate features down to the micro scale have made its use in medical devices and research feasible. A range of life-saving technologies can take advantage of 3Dprinting to go from bench top technologies into the field. This technology can be applied to medical diagnosis of patients in at-risk populations. Cells are able to detect and react to their environment. We can take advantage of this to design genetically modified cells for disease diagnosis. However, genetically modified cells are heavily regulated and it is thus difficult for use outside the lab. However, by containing them within a 3D-printed enclosure, these technologies can serve as vehicles to translate life-saving diagnosis technologies from the laboratory and into the field where the lower cost would allow more people to benefit from inexpensive diagnosis. Also, the genetically modified biosensors would be contained with a seal, ensuring that the genetically modified cells are unable to escape into the environment without user input.
In addition, 3D-printing can also be applied to reduce the cost of lab-based technologies. Cell patterning technology is a target of interest for applying more cost-effective technologies in order to understand how cells self-pattern and move in their environment. This may help explain the mechanics of cancer and other diseases. Through the use of a 3D-printed stamp, bacterial cells can be patterned without the use of expensive facilities, thus lowering the entry-barrier for researchers to explore cell patterning.
With the commercialization of 3D-printing, an opportunity has arisen to transition lifesaving technologies into more cost-effective versions of existing technologies. This would not only allow more research into existing fields, but also to ensure that potentially life-saving technologies reach the people that need them.
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