• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 2
  • Tagged with
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Effects of Bepridil on I_<Kr> and I_<Ks> of Rabbit Ventricular Myocytes

KODAMA, Itsuo, LU, Zhibo, KAMIYA, Kaichiro 12 1900 (has links)
国立情報学研究所で電子化したコンテンツを使用している。
2

Voltage-Dependent Effects of Bepridil on D540K HERG Channels

NIWA, Ryoko, LU, Zhibo, HONJO, Haruo, KAMIYA, Kaichiro 12 1900 (has links)
国立情報学研究所で電子化したコンテンツを使用している。
3

Bepridil Blockade of Ca<sup>2+</sup>-Dependent Action Potentials in Vascular Smooth Muscle of Dog Coronary Artery

Harder, David R., Sperelakis, Nick 01 January 1981 (has links)
The effect of the new vasodilatory and antianginal compound, bepridil (CERM-1978), was examined on the electrical activity of the vascular smooth muscle of isolated dog coronary arteries. Tetraethylammonium (10 mm) was used to induce excitability in the muscle in the form of Ca2+-dependent overshooting action potentials, whose inward current is carried almost exclusively by Ca2+ ion through voltage-dependent slow channels. Bepridil (5 × 10-7-1 × 10-5 M) produced a dose-dependent depression of the rate of rise and amplitude of these Ca2+ spikes. Complete blockade of the action potentials occurred at 1 × 10-5 M bepridil. These effects of bepridil were antagonized by elevation of external Ca2+ concentration ([CA]o). The effects of bepridil were substantially reversed by washout after about 30 min. Bepridil (10-5 M) also produced a small but significant (p < 0.05) increase in resting membrane resistance (input resistance increased from a mean of 10.1 to 12.4 mΩ), accompanied by a small but significant (p < 0.05) depolarization of 6 m V (from a mean of -51 to -45 mV). These latter effects are consistent with a diminution of the resting K+ conductance (gK) by bepridil. It is concluded that the vasodilatory and antianginal properties of bepridil may be explained by the action of this drug in depressing and blocking the Ca2+ influx into the cells, presumably by acting directly on the voltage-dependent slow channels in the cell membrane, and thereby lowering [Ca]i and thus the degree of contraction. Bepridil has Ca2+-antagonistic (or Ca2+ entry blocking or slow channel blocking) properties much like verapamil, but it is somewhat less potent than verapamil in this action (i.e., complete blockade occurred at 10-5 M bepridil vs. 2 × 10 -6 M verapamil.).

Page generated in 0.03 seconds