The current study examined the relationship of parental support, parental psychological control, and best friend support among Latino adolescents and loneliness using self-esteem as a mediating variable. The sample included 839 Hispanic (primarily Mexican) 9th – 12th graders from west Texas area school districts who were given a self-reported survey to assess parental behaviors and adolescent depression. Using structural equation modeling (SEM), findings indicated that neither maternal nor paternal support was found to be significantly related to loneliness in girls. Only maternal support was found to be significantly related to loneliness in boys. On the other hand, neither maternal nor paternal support was found to be significantly related to self-esteem in boys, while maternal support was found to be significantly related to self-esteem for girls. Results also indicate an interesting cross-gender relationship for loneliness with maternal psychological control significantly related to loneliness for boys but not for girls, and paternal psychological control significantly related to loneliness in girls but not for boys. Best-friend (peer support) was found to be significantly related to loneliness for girls but not for boys. Results indicate that maternal psychological control was significantly related to self-esteem for boys and girls. Results also indicate that paternal psychological control was significantly related to self-esteem for boys and girls. Results also indicate that family structure was found to be significant for girls and its relationship with loneliness. Results are discussed along with implications for therapists working with Latino populations.