Abstract Background: Musculoskeletal discomfort is common among professional orchestra musicians and according to the literature some anatomical areas, such as the neck, upper back and upper extremities, seem to be more frequently affected than others. There are also suggestions made that general joint hypermobility could be a potential risk factor for musculoskeletal discomfort among musicians. Furthermore, there seems to be a higher perceived feeling of psychosocial demands and stress among musicians in comparison to the general workforce. Aim: Investigate the prevalence of, and associations between, musculoskeletal discomfort, general joint hypermobility, psychosocial factors and stress among Swedish big band musicians. A further aim was to investigate associations between musculoskeletal discomfort, general joint hypermobility, psychosocial factors and stress, respectively. Method & Material: This study was part of a larger national survey on professional orchestra musicians in Sweden. This study focused on professional jazz musicians and included data from all three professional big bands in Sweden. The study presents the prevalence of musculoskeletal discomfort, general joint hypermobility, psychosocial factors and stress among professional Swedish big band musicians. 32 musicians completed the survey. Results: The study showed a high prevalence of musculoskeletal discomfort and general joint hypermobility. There were no statistically significant relationships between musculoskeletal discomfort and general joint hypermobility but between psychosocial demands and musculoskeletal discomfort in the anatomical subgroup low back/hip, and between negative stress and musculoskeletal discomfort in the anatomical subgroup low back/hip. Conclusion: In accordance with existing studies on classical orchestra musicians, this study found a high prevalence of musculoskeletal discomfort and general joint hypermobility among Swedish big band musicians. There was a statistically significant association with the relationship between psychosocial demands and musculoskeletal discomfort in the anatomical subgroup low back/hip and between negative stress and musculoskeletal discomfort in the anatomical subgroup low back/hip. Key words: big band musicians, musculoskeletal discomfort, general joint hypermobility, psychosocial factors, stress.