A critical and important part of the medical diagnosis is the montioring of the biopotential signals. Patients are always connected to a bulky and mains-powered instrument. This not only restricts the mobility of the patients but also bring discomfort to them. Meanwhile, the measureing time can not last long thus affecting the effects of the diagnosis. Therefore, there is a high demand for low-power and small size factor ambulatory biopotential measurement systems. In addtion, the system can be configured for different biopotential applications.The ultimate goal is to implement a system that is both invisible and comfortable. The systems not onlyincrease the quality of life, but also sharply decrease the cost of healthcare delivery. In this paper, a continuously tunable gain and bandwidth analog front-end for ambulatory biopotential measurement systems is presented. The front-end circuit is capable of amplifying and conditioning different biopsignals. To optimize the power consumption and simplify the system architecture, the front-end only adopts two-stage amplifiers. In addition, careful design of the critical transistors eliminates the need of chopping circuits. The front-end is pure analog without interference from digital parts like chopping and switch capacitor circuits. The chip is fabricated under SMIC 0.18 μm CMOS process. The input-referred noise of the system is only 1.19 μVrms (0.48-2000Hz).Although the power consumption is only 32.1 μW under 3V voltage supply, test results show that the chip can successfully extract biopotential signals.