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Ultrasonic imaging of the structure and elasticity of the carotid bifurcationJackson, Joel R. 05 1900 (has links)
No description available.
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A fluid mechanic assessment of the total cavopulmonary connectionEnsley, Ann Elizabeth 05 1900 (has links)
No description available.
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Blood flow evaluation using an intracoronary doppler catheterNewton, Bradley Scot 05 1900 (has links)
No description available.
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Hemodynamic wall shear stress in models of atherosclerotic plaques using phase contrast magnetic resonance velocimetry and computational fluid dynamicsKarolyi, Daniel Roberts 05 1900 (has links)
No description available.
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The prevalence of preclinical atherosclerosis in a healthy adult populationGriffith, Garett J. 03 May 2014 (has links)
Cardiovascular disease (CVD) is a progressive disease that presents signs, such as abnormal thickening or stiffening of arteries, early in its preclinical stage, and screening tools such as carotid intima media thickness (CIMT) measurement and pulse wave velocity (PWV) assessment have the potential to identify individuals prior to the clinical manifestation of CVD. The purpose of this study was to determine the prevalence of preclinical atherosclerosis, as indicated by high CIMT and PWV values, in an adult population aged 40-70 years and free of diagnosed CVD using these screening tools. Secondarily, this study aimed to compare established CVD risk factors and other health parameters between those with elevated or normal arterial health values. Sixty subjects made 2 visits to the Ball State University Human Performance Laboratory. The first visit included basic anthropometric measurements as well as assessment of CIMT and PWV. After a one week objective physical activity assessment, subjects returned to the HPL for assessment of blood lipids and body composition via dual energy x-ray absorptiometry scan. Prevalence of preclinical atherosclerosis was calculated from the total sample as well as within both genders, and an independent samples t-test was conducted in order to identify significant differences in health characteristics between those in the normal and high groups. Abnormal CIMT or PWV values were present in 43% of study subjects; 30% and 18% of the test sample met the criteria for elevated CIMT and PWV, respectively. Significant differences existed between normal and high CIMT and PWV study groups for physical activity, body composition, and blood lipid profile variables. Comparisons within each gender revealed differences in health profile elements. Both the CIMT and PWV measurement techniques may be valuable additions for community CVD screenings, as certain health profile abnormalities may impact each marker of arterial health differently. Additional research is needed in order to determine the cost-effectiveness of these screening tools as a preventive health method. / School of Physical Education, Sport, and Exercise Science
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Measurement of blood flow through proton activation of positron emitting tracersMiller, Thomas James January 1981 (has links)
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1981. / MICROFICHE COPY AVAILABLE IN ARCHIVES AND SCIENCE. / Bibliography: leaf 186. / by Thomas James Miller, Jr. / M.S.
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Quantitative and continuous measurement of cerebral blood flow by a thermal methodWei, Datong January 1993 (has links)
No description available.
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An evaluation of the use of transcutaneous oxygen pressure measurement in the non-invasive vascular laboratory : with special reference to selection of amputation level.Mars, Maurice. January 2001 (has links)
Transcutaneous oxygen pressure measurement (TCp02) using a miniaturised Clarke electrode
and a heating thermistor was developed independently by Huch et al and Eberhardt et al in
1972. After its initial use to non invasively monitor arterial partial pressure (Pa02) in neonates
it was proposed as a useful test of skin blood flow and possibly amputation wound healing
level selection in patients with peripheral vascular disease. Unfortunately a wide range of
predictive values emerged with some authors reporting amputations healing when the TCp02
value was 0 mmHg. The investigation, while still considered useful, has not gained
widespread support.
This study investigates the use of TCp02, establishes a value for the use of the TCp02 Index to
predict amputation wound healing potential and examines the hypothesis that the use of the
TcpO Index to select amputation level can reduce patient morbidity and mortality.
The literature is reviewed and a series of studies evaluating TCp02 use, undertaken in the
Durban Metropolitan Vascular Service Non-Invasive Laboratories, are presented. TCp02
measurements were performed in a standardised manner with the subject supine breathing
room air. Measurements were taken at fixed sites, on the mid dorsum of the foot (Foot), 10
cm distal to the tibial tuberosity and 2 cm lateral to the anterior tibial margin (BKA), 10 cm
proximal to the patella in the midline (AKA) and on the chest in the mid-clavicular line. A
TCp02 Index, the limb to chest ratio was defined.
TCp02 data derived from control subjects asymptomatic of peripheral vascular disease were
shown to be similar to age matched pooled data derived from the literature. In patients with
peripheral vascular disease, absolute TCp02 and the TCp02 Index were shown to fall from
proximal to distal sites and again were no different to pooled data derived from the literature.
Based on presenting symptoms, the fall in TCp02 and the TCp02 Index was significant from
proximal to distal sites. The reduction in absolute TCp02 and the TCp02 was also related to the
most distal pulse present. TCp02 values were found to be no different in patients with
peripheral vascular disease with or without diabetes.
When comparing TCp02 and the TCp02 Index with Doppler pressure measurements at the
Popliteal artery and at the foot, and the Doppler ankle brachial index (ABI), Doppler derived
data were significantly higher in diabetic patients than in non-diabetic patients. No differences
were noted in TCp02 data. TCp02 was compared with the 133Xe radio-isotope skin washout
test. The best correlation was (r = 0.46) was obtained with a logarithmic curve
y = 10.862Ln(x) + 38.751.
TCp02 was compared with antibiotic concentrations (Cefoxitin) in muscle obtained from the
site of amputation and the Cefoxitin Index, the ratio of muscle antibiotic concentration to
plasma concentration, as an indication of the relationship of skin TCp02 to muscle blood flow.
A significant correlation was shown between the Cefoxitin Index and TCp02 (r = 0.67,
p = 0.035) and the TCp02 Index (r = 0.64, P = 0.045), suggesting that skin oxygen delivery
may reflect muscle antibiotic delivery and hence blood flow.
TCp02 and the TCp02 Index were compared with heated and unheated laser Doppler
fluxmetry (LDF) in 35 patients undergoing amputation wound healing assessment. Significant
correlations were shown between heated LDF, heated LDF Index and the TCp02 Index
(r = 0.63 and r = 0.69, P < 0.0001). TCp02 Index values of 0.5 and 0.55 showed an accuracy
of 96.2 % in predicting amputation outcome while LDF values of 3, 4 and 5 arbitrary units
gave an accuracy of 88.5 %. Using receiver operator curves, a TCp02 Index of 0.55 was
shown to be the best test.
Over the years 1987 and 1988, TCp02 data were gathered on 193 patients undergoing lower
limb amputation for peripheral vascular disease. Information on the outcome of the
amputation was available for 152 amputations. Circumstances which might result in a reduced
pre-operative TCp02 reading were identified and criteria were set for the use of TCp02 to
predict amputation wound healing potential. 122 amputations which met the defined entry
criteria were available for evaluation. A TCp02 Index of 0.50 gave a definitive predictive
value below which no amputation healed. Similarly no amputation with an absolute TCp02 of
less than 27 mmHg healed. Receiver operator characteristic curves showed the TCp02 Index
to be a better test than absolute TCp02. A TCp02 Index of 0.55 was shown to have the best
sensitivity of96.7 %, with a specificity of79.8 % and an accuracy of 90.2 %.
When introduced to clinical practice, correct use of the TCp02 Index of 0.55 resulted in a
reduction in amputation revision rate from 40.3 % in 1987, to 8.2 % in 1990. Initially some
surgeons felt that the TCp02 Index predicted amputation wound failure at distal sites at which
healing could be expected on clinical criteria, and chose amputate at sites with a TCp02 Index
value less than 0.55. These amputations failed to heal. As surgeons gained confidence in the
test, they chose to follow the TCp02 data more often and the percentage of amputations
performed at sites predicted by the TCp02 Index to fail , fell from 35.5 % in 1987 to 6.6 % in
1990.
Over a 15 year period at King Edward VIII Hospital, the amputation revision rate has fallen
from an average of 32.7 % in the first five years when Tcp02 data were not available to the
surgeon, to 21.4 % and 22.9 % in the two subsequent 5 year periods when Tcp02 data were
available. The mortality rates were unchanged. The decline in revision rates was less than
expected and relates to the fact that approximately only 42 % of patients requiring amputation
undergo the test. This is because it is time consuming and available only during weekday
office hours.
These studies have confirmed the usefulness of Tcp02 measurement in the non-invasive
vascular laboratory. The index is shown to be superior to absolute Tcp02 as a predictive test
of amputation wound healing. The introduction of several criteria to define when Tcp02 use is
appropriate has refined the investigation and made it clinically useful in our setting. A Tcp02
Index of 0.55 in the appropriate patient is a useful test to predict amputation wound healing
and its use has resulted in reduced patient morbidity and mortality, confirming the hypothesis
tested. / Thesis (M.D.)-University of Natal, 2001.
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Laser doppler assessment of gastric mucosal blood flow in normals and its relationship to the systemic activity of growth peptides in healing and non healing gastric ulcers.Clarke, D. L. January 1999 (has links)
The pattern of mucosal blood flow in normal human stomachs, and benign
gastric ulcers was assesed with laser Doppler flowmetry and the relationship
between a single determination of ulcer blood flow and the systemic level of
growth factors was investigated.
A significant ascending gradient in mucosal blood flow from the antrum to
fundus was demonstrated. Different levels of cellular activity in the regions of the stomach may explain this gradient. In the gastric ulcers that healed on standard medical therapy mucosal blood flow was significantly increased in comparison to normal stomachs. In the ulcers that were refractory to standard medical therapy mucosal blood flow was significantly lower than in normal stomachs and healing ulcers. Higher systemic levels of the growth factor bFGF were demonstrated in healing ulcers compared to non-healing ulcers.
Gastric mucosal blood flow can increase in response to the increased
metabolic demands of healing, however impairment of this response may be
an important factor preventing healing of benign gastric ulcers. It would
appear that non-healing of gastric ulcers can be predicted at initial diagnosis by reduced peri-ulcer gastric mucosal blood flow and low blood levels of bFGF. / Thesis (M.Med.Sc.)-University of Natal, Durban, 1999.
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A computational fluid dynamic study of blood flow through stenosed arteries / by Keng Cheng Ang.Ang, Keng Cheng January 1996 (has links)
Errata has been inserted inside back pages. / Bibliography: leaves 180-186. / viii, 186 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Effects of stenoses on characteristics such as pressure drops, flow velocities and shearing stresses on the arterial walls are examined and their significance on the progression of arterial diseases is discussed. / Thesis (Ph.D.)--University of Adelaide, Dept. of Applied Mathematics, 1996
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