No abstract available. / Thesis (M.Sc.)-University of Natal, Durban, 1991.

No abstract available. / Thesis (M.Sc.)-University of Natal, Pietermaritzburg, 1996.

This thesis presents results from investigations of secondary metabolites from marine organisms. The first part pursued the isolation of new compounds from soft bodied marine organisms, the study of aqueous extracts from the different algae and soft bodied marine organisms permitted the selection of one extract from the red alga <i>Laurencia </i>sp., from which six new sesquiterpenes cyclic ethers were isolated. The investigation of the sponge <i>Stylotella aurantium </i>collected from Fijian waters, resulted in isolation of seven previously reported pyrrole alkaloids. The second part focused on the exploration of three novel actinomycete microbes isolated from Mariana Trench sediment, collected at depth 10,898 m (Challenger Deep; 11°19’911’’ N; 142°12’372’’E) for the production of bioactive compounds. Seven novel phenazine alkaloids, dermacozines (A-I), were isolated from the fermentation broth of two Mariana Trench microbes <i>Dermacoccus abyssi</i> strain MT1.1 and <i>Dermacoccus </i>strain MT1.2. The investigated cytotoxic activity against leukaemia cell line (K562) showed that dermacozine F and G have moderate activity with IC_50s of 9 and 7 <i>μ</i>M, respectively, while the highest radical scavenger activity was observed with dermacozine C with an IC₅₀ value of 21 <i>μ</i>M. Investigation of <i>Micromonspora</i> sp. isolated from Mariana Trench sediment led to the isolation of six compounds including: one unusual depeptide and the known deferoxamine together with four known diketopiprazines. Finally, the last part of work focused on the investigation of molecular basis of cold temperature and high pressure adapted growth in extremophilic microbes such as <i>Photobacterium profundum sp.</i> The overall aim of this project was to understand more about the high pressure and cold-adapted growth of two novel <i>P. profundum</i> strains SS9R (Piezophile) and 3TCK (Piezosensitive) by studying the surface of polysaccharides which play an important role in the cold-adapted growth of <i>P. profundum</i> <i>SS9.</i>

A Dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the Degree of Master of Science. / An outline of reported synthetic routes to the Lupine alkaloids, epilamprolobine [2] and lamprolobine [3] and a review of the use of vinylogous amides and urethanes as precursors for the synthesis of alkaloids are presented in Chapter 1. This is followed by a presentation of our strategy for synthesis of the two Lupine alkaloids. Vinylogous cyanamide intermediate 1- (3-hydroxypropyl) -2- cyanomethylenepiperidine [68] plays a key role in this strategy, since exploitation of its ambident nucleophilicity forms the central theme of this project, The successful route to the intermediate [68] involved the preliminary preparation of the tertiary thiolactam, 1-(2- ethoxycarbonylethyl)piperidine-2-thione [83][ by thiation of the secondary lactam 2-piperidinone [72] and conjugate addition at nitrogen with ethyl acrylate in a Michael reaction. Sulphur extrusion of the salt made from [83] and bromoacetonitrile and subsequent reduction of the ester group provided the pivotal vinylogous cyanamide intermediate. A number; of alternative routes based on 5- bromopentanoic acid [80], 1-allyl-2-piperidinone [73] and thiolactams [84J and [105] were unsuccessful. Cyclisation of the intermediate [68] was achieved by an intramolecular c-alkylative ring closure via the corresponding tosylate [l16] to forln an unsaturated functionalised quinolizidine [69]. Stereoselective carboncarbon double bond reduction and nitrile reduction resulted in the synthesis of two quinolizidines. lupinamine [11] and epilupinamine [112]. Further transformations led to the formation of the derivatives, N-acetyllupinamine [113] and N-acetylepilupinamine [114], and also to the target alkaloids, epilamprolcbine [2] and lamprolobine [3]. / Andrew Chakane 2018

Typescript. Bibliography: leaves 51-61.

"October 2002" / Includes bibliographical references (leaves 172-183) / x, 183 leaves : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Horticulture, Viticulture and Oenology, 2002

The Two-eyed Seeing Garden is an ethnobotanical garden that is a living description of the interrelationships between land, plants and people that explicates two ways of seeing. The goal of the Two-eyed Seeing Garden is to combine two frameworks, one of Indigenous Traditional Knowledge and one of Western Scientific Knowledge, in an attempt to create a bridge between the two knowledges in order for the inter-relationships between the two systems to be made visible. The Two-eyed Seeing Garden emphasizes the worldview of Indigenous Ecological Knowledge as an independent valid knowledge system that describes local knowledge in connection with other local knowledges, nearby and far away. These knowings can be thought of as layers that begin to intersect and eventually connect the same way as ripples do in a pond. Small and central, yet moving out. The physical garden is this too. It is a small place that is nested within a larger region. Although it may have walls and be distinct from it’s immediate surroundings, it can connect to the larger region. The Two-eyed Seeing Garden is an example of wholeness and connectivity from its most minute aspects to its situatedness in the larger context. The relationships make the invisible visible and describe the co-creation and co-existence of all those that inhabit this land now and since time immemorial.

The Two-eyed Seeing Garden is an ethnobotanical garden that is a living description of the interrelationships between land, plants and people that explicates two ways of seeing. The goal of the Two-eyed Seeing Garden is to combine two frameworks, one of Indigenous Traditional Knowledge and one of Western Scientific Knowledge, in an attempt to create a bridge between the two knowledges in order for the inter-relationships between the two systems to be made visible. The Two-eyed Seeing Garden emphasizes the worldview of Indigenous Ecological Knowledge as an independent valid knowledge system that describes local knowledge in connection with other local knowledges, nearby and far away. These knowings can be thought of as layers that begin to intersect and eventually connect the same way as ripples do in a pond. Small and central, yet moving out. The physical garden is this too. It is a small place that is nested within a larger region. Although it may have walls and be distinct from it’s immediate surroundings, it can connect to the larger region. The Two-eyed Seeing Garden is an example of wholeness and connectivity from its most minute aspects to its situatedness in the larger context. The relationships make the invisible visible and describe the co-creation and co-existence of all those that inhabit this land now and since time immemorial.

No description available.

Thèse de doctorat : Sciences physiques : Paris, Faculté des sciences : 1870. / Titre provenant de l'écran-titre.