My doctoral work has addressed the anatomy-function relationship by illustrating 1) the unique topology of brain anatomy for biologically plausible functional connectome to exist, 2) a higher vulnerability of neuroanatomy against the genetic control for a brain hub region, whereas lower genetic influence on its functional fingerprints, and 3) a global functional plasticity following a local injury beyond its anatomical boundaries. All together, the work here has demonstrated the interplay between brains structure and function, as well as the impact of familial relatedness (heritability) on these measures.