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Mathematical Models of CancerBozic, Ivana January 2012 (has links)
Major efforts to sequence cancer genomes are now occurring throughout the world. Though the emerging data from these studies are illuminating, their reconciliation with epidemiologic and clinical observations poses a major challenge. Here we present mathematical models that begin to address this challenge. First we present a model of accumulation of driver and passenger mutations during tumor progression and derive a formula for the number of driver mutations as a function of the total number of mutations in a tumor. Fitting this formula to recent experimental data, we were able to calculate the selective advantage provided by a typical driver mutation. Second, we performed a quantitative analysis of pancreatic cancer metastasis genetic data. The results of this analysis define a broad time window for detection of pancreatic cancer before metastatic dissemination. Finally, we model the evolution of resistance to targeted cancer therapy. We apply our model to experimental data on the response to panitumumab, targeted therapy against colorectal cancer. Our modeling suggested that cells resistant to therapy were likely present in patients’ tumors prior to the start of therapy. / Mathematics
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Some limit theorems for a one-dimensional branching random walk.Russell, Peter Cleland January 1972 (has links)
No description available.
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A measurement of the branching ratio of pi[superscript 0] -> e[superscript+] e[superscript-] using K[subscript L] -> 3pi[superscript 0] decays in flight /Zimmerman, Eric D. January 1999 (has links)
Thesis (Ph. D.)--University of Chicago, Dept. of Physics, March 1999. / Includes bibliographical references. Also available on the Internet.
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On the decay branching ratio of long-lived neutral kaons into two muons /Ambrose, David Alan, January 1998 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 1998. / Vita. Includes bibliographical references (leaves 324-331). Available also in a digital version from Dissertation Abstracts.
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Analysis of genes that regulate flowering and branch initiation in the shoot apex of Nicotiana tabacum and Arabidopsis /Ahearn, Kelly Patricia, January 2000 (has links)
Thesis (Ph. D.)--University of Oregon, 2000. / Typescript. Includes vita and abstract. Includes bibliographical references (leaves 50-54). Also available for download via the World Wide Web; free to University of Oregon users. Address: http://wwwlib.umi.com/cr/uoregon/fullcit?p9963440.
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Vergleichende Untersuchungen über Bau und Inhalt normaler und abnorm angeschwollener Äste von Tilia grandifoliaBergström, J. B. January 1914 (has links)
Thesis (doctoral)--Universität Bern, 1914. / Includes bibliographical references (p. 64-65).
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NRAGE in Branching Morphogenesis of the Developing Murine KidneyNikopoulos, George N. January 2009 (has links) (PDF)
No description available.
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The effect of red light as a fall treatment on branching of rhododendron.Kasperek, Laurie Beth Menzel 01 January 1983 (has links) (PDF)
No description available.
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PARAMETRIC EXPLORATION OF BRANCHING IN CPS TOWARDS THE APPLICATIONS OF MICRONEEDLES AND MICRO-VELCROGOPALAKRISHNAN, APARNA 23 May 2005 (has links)
No description available.
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Aspergillus Fumigatus Ras Homologs Regulate Vegetative Growth, Development and VirulenceFortwendel, Jarrod R. January 2005 (has links)
No description available.
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