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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Mechanisms of MUC1/ICAM-1 signalling in breast cancer metastasis

Bernier, Ashlyn Unknown Date
No description available.

Symptom clusters among Chinese women with breast cancer

Chau, Hau-yan., 周厚仁. January 2012 (has links)
Background: breast cancer patients were found to experience multiple concurrent symptoms. These concurrent symptoms (termed symptom cluster) could have synergistic effects on patient functional status and quality of life. Understanding symptom cluster provided us new insight in symptom assessment and symptom management. Previous studies on symptom cluster among breast cancer patients focused on Caucasian. The current study attempt to identify symptom cluster and the factors associated with it among Chinese breast cancer patients. Methods: this study was a secondary analysis on a sample of 348 breast cancer patients. Data on symptom distress (assessed by Memorial symptom Assessment scale Short Form) was retrieved. Symptom clusters were identified through factor analysis using principal components method and Varimax rotation. Demographics and medical characteristics were proposed to be associated with symptom cluster. Uni-variate analysis and linear regression performed on these variables. Results: four symptom clusters (namely gastrointestinal cluster, general malaise cluster, self image cluster, and cutaneous cluster) were identified. Recurrence of breast cancer and chemotherapy were associated with either gastrointestinal cluster or general malaise cluster. Age, cancer status and occupation were associated with self image cluster while no variable was associated with cutaneous cluster. Conclusion: The current study provided empirical evidence that Chinese breast cancer patients experienced similar symptom clusters as Caucasian. Future study could be done to verify these four symptom clusters and identify underlying mechanism. Recommendations: health care providers could pay more attention to those suffer from breast cancer recurrence or currently receiving chemotherapy. These patients tend to experience gastrointestinal cluster and general malaise cluster. Clinical setting and evaluation tools could be adjusted to fit these high risk groups. / published_or_final_version / Public Health / Master / Master of Public Health

New drug development in breast cancer

郭心鈴, Kwok, Sum-ling. January 2008 (has links)
published_or_final_version / Community Medicine / Master / Master of Public Health

Mechanisms of growth inhibition induced by methylene-substituted and ring-substituted dims in breast cancer cells

Vanderlaag, Kathryn Elisabeth 15 May 2009 (has links)
One in 8 women will be diagnosed with breast cancer in the United States and estrogen receptor (ER) status largely influences the type and subsequent success of treatment employed. Although ER-positive breast cancer can be treated with endocrine therapy, the more invasive ER-negative breast cancer is non-responsive to this therapy and cytotoxic agents are often utilized which are associated with many adverse side effects. Consequently, there is a genuine need to develop more effective, less toxic treatments for invasive breast cancer. Indole-3-carbinol is a phytochemical found in cruciferous vegetables and one of its major metabolites, 3,3’-diindolylmethane (DIM), exhibits a broad range of anticancer and antitumorigenic activities. ER-negative MDA-MB-231 and MDA-MB-453 breast cancer cell growth was inhibited after treatment with a novel series of methylenesubstituted DIMs (C-DIMs), namely 1,1-bis(3’-indolyl)-1-(p-substitutedphenyl) methanes containing trifluoromethyl (DIM-C-pPhCF3), t-butyl (DIM-C-pPhtBu) and phenyl (DIM-C-pPhC6H5) groups. In addition, DIM-C-pPhC6H5 (40 mg/kg/d) inhibited tumor growth in nude mice bearing MDA-MB-231 cells as xenografts. Treatment of breast cancer cells with C-DIMs lead to downregulation of cyclin D1 and induction of non-steroidal anti-inflammatory drug-activated gene 1. Detection of necrosis, caspasedependent or caspase-independent apoptosis were not observed in breast cancer cells treated with C-DIMs, however autophagic cell death was induced by C-DIMs. DIM and ring-substituted DIMs have exhibited antitumorigenic activity in tumor murine mammary models. An investigation into the mechanism of cell death induced by DIM and 5,5’-dibromoDIM (5,5’-diBrDIM) in both ER-positive (MCF-7) and ERnegative (MDA-MB-231) breast cancer cells revealed modulation of several key signaling pathways involved in growth control. Both DIM and 5,5’-diBrDIM downregulated cyclin D1, although only 5,5’-diBrDIM induced a depolarization of the mitochondrial membrane. In addition, apoptosis was observed in MCF-7 cells treated with 5,5’-diBrDIM but not MDA-MB-231 cells. In summary, C-DIMs may represent new mechanism-based agents for treatment of breast cancer through induction of autophagic cell death. The ring-substituted DIMs correspond to a novel class of uncharged mitochondrial poisons that are also highly effective in inhibiting breast cancer cell growth. Results of this research provide evidence for the potential role of two new series of DIM analogs for the treatment of highly aggressive breast cancer.

A clinical guideline to minimise radiation-induced dermatitis in women with breast cancer

Chu, Wai-ling. January 2008 (has links)
Thesis (M.Nurs.)--University of Hong Kong, 2008. / Includes bibliographical references (p. 140-149)

A structural analysis of the impact of breast cancer on positive and negative domains of quality of life

Kerenyi, Laura Maria. January 2007 (has links)
Thesis (Ph.D.)--State University of New York at Buffalo, 2007. / Title from PDF title page (viewed on July 22, 2009). Department of Counseling, School, and Educational Psychology, State University of New York at Buffalo. Advisors: James Donnelly, Michael Zevon. Includes bibliographical references (leaves 88-104).

Socioeconomic concerns, family roles and relationships of the breast cancer patient

Jessup, Margot Anne January 1978 (has links)
The purpose of this study was to explore the socioeconomic needs and concerns of a group of new breast cancer patients and their families with consideration of changes in roles and relationships and patient's feelings about self. The study was conducted in co-operation with the A. Maxwell Evans Clinic, a cancer treatment centre under the direction of the Cancer Control Agency of British Columbia. The scope of this study was restricted to new breast cancer patients referred to the New Patients Clinic in May, 1978 and their primary care-givers. In this study, the primary care-givers were family members most responsible for the patient's rehabilitation. The sample consisted of 16 patients and 14 primary care-givers. Two of the patients' primary care-givers were not available at the time of the interview. The sample included patients with breast cancer in Stages 1, 2, 3 and 4. One interview schedule was designed for the patient and a shorter form for the primary care-giver. An open-ended question about the patients and primary care-givers' greatest concerns were included to identify needs not covered by scheduled topics and to give respondents an opportunity to expand and priorize concerns. Socioeconomic change was defined in terms of changes in place of residence, work activities outside the home, family roles and responsibilities, relationships with family and friends, and feelings about self. The findings indicated that the area of greatest change was in family roles and relationships. Most primary care-givers were interested in talking to the interviewer about some anxieties concerning their new role as primary care-giver. Some primary care-givers also were interested in more information about how to create a rehabilitative environment for the patient. All patients were generally positive toward the Clinic. Several patients expressed a number of suggestions for improving support services and offered ideas about . the attitudes of significant others which affect the patient's sense of well-being and ability to recover. The researcher makes some recommendations for enhancing and developing supportive services for the consideration of the medical team and the specialized social services department in a cancer clinic. The recommendations include approaches to help families recognize and develop new roles to help the patient recover. / Arts, Faculty of / Social Work, School of / Graduate

A vitamin and mineral mega-dose treatment for non-metastatic breast cancer patients : a historical comparison study

Vanderlaan, Angelia Selena May. 10 April 2008 (has links)
No description available.

Receptor status in recurrent breast cancer-a retrospective study

Ally, Zain January 2017 (has links)
MBBCh Department of Surgery University of the Witwatersrand 08 March 2017 / Background: Breast cancer recurrence is a major clinical event and represents a principal cause of breast cancer related death. A discordance rate between receptor status of primary and matched recurrence tumours has been reported in the literature but the extent of this in our population is unknown. Repeating Immuno-histochemistry (IHC) and fluorescent in-situ hybridization (FISH) studies have financial and workforce implications in a resource-constrained environment. However, the results of these receptor studies have prognostic implications. Therefore it is important to determine the extent of change in receptors in the recurrence. Aim: To compare the hormone receptor profile between breast cancer primary and matched loco-regional recurrence and to ascertain the extent of receptor discordance. Methods: All patients who presented to the respective breast care facilities for breast cancer recurrences between 2006 and 2014 were identified using the mammography department records. The specimens for each patient were scrutinized. Oestrogen receptor (ER) and progesterone receptor (PgR) status as well as the Human Epidermal growth factor type 2 receptor (HER2) receptor statuses were noted for each patient and a comparison was made between primary and matching recurrence, with loss and gain being noted. Results: In the analysis, significant discordance was found for matching hormone receptor status. Discordance in oestrogen receptor status occurred in 14.3% of cases: change occurred both from ER-positive to -negative and vice versa. For progesterone receptor status this occurred in 25.7% of cases. A discordance of 14.8% was noted for HER2 receptor status. These results are not dissimilar to what has been previously reported in the literature. Of note, adverse receptor discordance: positive to negative was noted in a total of 19 receptors (ER 4; PgR 11; HER2 4) Conclusion: These results confirm the phenomenon of receptor discordance between breast cancer primary and recurrence. The results support the necessity of confirming receptor status on all loco-regional recurrent disease. This reinforces the importance of obtaining a confirmatory biopsy in patients where recurrence is suspected and therefore allowing the appropriate targeted therapy to be selected. / MT2017

A statistical classification of breast cancer patients by degree of nodal metastases

Wilson, Sandra Lee January 1977 (has links)
Recently the traditional primary method of treatment for breast carcinoma — the Halsted radical mastectomy — has been challenged. It is felt by some people that other methods may be more appropriate for certain women. Quality of life and the patient's preferences are being considered in addition to the strictly medical aspects of the problem. One procedure that attempts to increase the quality of life for certain women is the selective biopsy. Women who are proven to have lymph node metastases at the biopsy are spared a mastectomy and treated by radiation since surgery cannot remove all of the cancer. A study was undertaken at the British Columbia Cancer Institute of selective biopsy patients diagnosed between 1955 and 1963 in order to assess the procedure in British Columbia. After studying survival for selective biopsy patients and others, it was concluded that the procedure should continue to be recommended. Since only 14% of the patients now referred to BCCI have had a selective biopsy, I decided to try to find a statistical method for assessing the probability of nodal metastases. The problem is one of statistical classification. The literature on the theory of several statistical models was reviewed. Two models were chosen for the problem: linear discriminant analysis and logistic regression. The classification procedure most often used is discriminant analysis. However, the linear discriminant model assumes a normal distribution and common covariance matrix for the vector of observations. Medical data is often non-normal and even discrete. The logistic probability model works well with such data. Both models were then used to study the selective biopsy problem. The patients of the BCCI study were used as a training set to estimate the parameters of the discriminant function and the logistic probability function. Then each estimated function was used to classify the patients as a measure of the goodness of fit of the models. The logistic regression correctly classified slightly more of the patients than the discriminant analysis did. Because of the iterative nature of the logistic regression, the execution time for the logistic regression was longer than for discriminant analysis, but not beyond practical limits. .The variables that were significant in the statistical analyses could be used to help the physician make a clinical assessment of the lymph nodes of a woman with breast carcinoma. The variables indicate areas where further research would be useful. / Science, Faculty of / Mathematics, Department of / Graduate

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