ABSTRACT Isopropyl Alcohol (denoted as IPA) is a valuable chemical product, which is used in the chemical industry such as synthetic resin, essential oils and surface paint. Moreover, factory of the production of photography and electronics are also the user of IPA.IPA is the typical pollutant emitted from those industrial processing . It is known to be causing severe irritation and burns and is suspected to have long-term effects such as bronchitis. This study was to investigate the effect on conversion, deactivation of long-term test, selectivity of product and kinetics in oxidation of IPA over Cu and Cu/Ce catalysts supported on ceramic honeycomb. The explanation of results can be divided into several major parts as follows: 1. In the of selection catalyst, we find that 20%Cu/Ce catalysts prepared by wet- impregnation has the best conversion and selectivity. 2. The conversion of IPA in catalytic reaction is increased with the increasing both of reaction temperature and influent concentration of oxygen but decreased with the going up of initial concentration of IPA, space velocity and relative humidity. 3. In the catalyst stability of long-term test, Cu/Ce catalysts had a good stability after 7 days reaction in heterogeneous reactor. The tests such as XRD, SEM and EA were also determined to verify the stability from surface of catalyst. 4. Two kinetic models, Power rate law and Mars-Van Krevelen model were used to fit the kinetic data of the decomposition of IPA. Power rate law is suitable to describe the catalytic decomposition of IPA under the operation range in this work.