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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Buddlejol, a new alpha-chymotrypsin inhibitor from Buddleja asiatica

Khan, F.A., Khan, N.M., Khan, H.U., Khan, S., Ali, N., Ahmad, S., Maitland, Derek J. January 2015 (has links)
No / Buddlejol (1), a new sterol, has been isolated from the ethyl acetate soluble fraction of the antispasmodic plant Buddleja asiatica along with stigmasterol (2), lignoceric acid (3), taraxerol (4) and alpha-amyrin (5), respectively. The structure of Buddlejol (1) was established as (24S)-stigmast-5,22-diene-7 beta-ethoxy-3 beta-ol by spectral analysis and comparison with closely related structures. Buddlejol revealed to be a competitive inhibitor of chymotrypsin with the Ki value of 10.60 A mu M as indicated by Lineweaver-Burk and Dixon plots and their re-plots against its chymotrypsin inhibition assay, while the other compounds showed less inhibitory potential. The bioassay-guided isolation was stimulated by the preliminary cytotoxic screening of various fractions of B. asiatica.
Buddleja asiatica
Ethyl acetate soluble fraction
Buddlejol
Cytotoxic activity
Chymotrypsin inhibition
Chemical-constituents
Medicinal-plants
Mechanism
Elastase
Tobacco
China
Lour

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