Efficacious timing and rate of synthetic fertilizer nitrogen (N) application can reduce the amount of N needed to be applied for potato production. The purpose of this study was to compare combinations of source, timing, and application methods of different synthetic N fertilizers on yield and quality of irrigated Russet Burbank, processing potato in Manitoba. Source, timing, and application method combinations were examined to provide a range of N availability over the growing season. This study was conducted at two sites over two years. Split applications of granular urea or Super-U, addition of ESN at planting and split application of granular urea at planting and fertigation were the most consistent treatments for highest marketable yield and nitrogen use efficiency. ESN was advantageous in wet site conditions. The results indicate split application of granular urea and split granular urea and fertigation that growers of processing irrigated potato primarily use in Manitoba are sound management practices. / February 2016