Owner-operator lack of knowledge about financial and operation costs is a serious impediment to business survival. The purpose of this correlational study was to examine the relationship between the knowledge of financial and operational costs among trucking owner-operators and their business performance. The theoretical framework for the study was the resource-based theory and knowledge gap theory. A convenience sample of 78 owner-operator truckers across the United States participated in this study. The response rate was 17% for a web-based survey that was distributed to owner-operators in Facebook, and 83% for the paper-based surveys from the owner-operators who were visiting more than 10 truck stops in Delaware, Maryland, New Jersey, and Pennsylvania. The findings from multiple linear regression analysis indicated a significant relationship between the trucking owner-operators' financial knowledge, operational costs knowledge, and financial performance. A significant relationship also existed between the financial knowledge of trucking owner-operators, operational costs knowledge, and nonfinancial performance. The findings of this study provide the owner-operator with a better understanding of factors that relate to business performance, which may inform their reasons for successes and failures. The implications for social change will occur if the failure rate of owner-operators declines and the opportunities for sustainable businesses increase. Sustainable owner-operator performance could lead to higher employment by the trucking industry and contribute to a better economy