Diss. (sammanfattning) Uppsala : Univ., 2003. / Härtill 4 uppsatser.

Ulm, Univ., Diss., 2008.

Proefschrift Rijksuniversiteit Groningen. / Datum laatste controle: 15-05-1997. Met bibliogr., lit. opg. - Met een samenvatting in het Nederlands.

Thesis (M. Nurs.)--University of Hong Kong, 2005.

The purposes of this study were to explore the relationships between uncertainty and quality of life indicators in patients recovering from coronary artery bypass graft (CABG) surgery and to investigate the differences in uncertainty and quality of life indicators between primary CABG patients and reoperation patients. The indicators of quality of life selected for this study were the patient's perception of health status and life satisfaction. A convenience sample of 41 primary CABG patients and 11 reoperation patients who were five to ten months postoperative completed the Mishel Uncertainty in Illness Scale (Community Version) (MUISCV), the General Health Rating Index (GHRI), the Cantril Self-Anchoring Scale, and a patient information sheet. Uncertainty, past life satisfaction, and present life satisfaction did not significantly differ between the primary and reoperation patients. Both groups of patients perceived moderately low uncertainty, and were moderately satisfied with their present lives. Trends in the ratings of past, present, and future life satisfaction suggested that CABG surgery was associated with an improvement in life satisfaction and optimism for the future in both primary CABG patients and reoperation patients. Reoperation patients' perceptions of health status and projections of future life satisfaction were significantly less favorable than those of the primary CABG patients suggesting that the quality of life following CABG surgery is lower for the reoperation patients. Uncertainty was significantly negatively associated with perceptions of health status, present life satisfaction, and future life satisfaction. This finding suggests that higher uncertainty is associated with a lower quality of life in CABG patients who are five to ten months postoperative. The findings were discussed in relation to theoretical expectations, other research studies, and the methodological problems inherent in the study. Implications of the findings for nursing practice were suggested. Recommendations for future research were made. / Applied Science, Faculty of / Nursing, School of / Graduate

No description available.

A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfillment of the requirements for the degree of Master of Medicine Johannesburg, 2017 / Background: Infections post cardiac surgery can have potentially devastating consequences. Adequate antimicrobial prophylaxis is therefore crucial to limit the occurrence of such complications. Cefazolin is a commonly prescribed prophylactic agent for major cardiac surgery requiring cardiopulmonary bypass (CPB). The effects of CPB on the pharmacokinetic profile of cefazolin are largely unknown. To date there is no published work determining the optimal bolus dosing of cefazolin required to achieve acceptable concentrations intra-operatively during and post CPB. Aim: The aim of this study was to describe the total serum cefazolin levels during elective valve replacement surgery on CPB at CMJAH. Method: A prospective, contextual, descriptive design was used in this study. Cefazolin plasma concentrations were analysed at specific pre-determined time intervals in adults patients scheduled for elective valve replacement surgery. Convenience sampling was used. Results: Sixteen patients were enrolled in the study with equal number of males and females, ranging from 18 years to 59 years of age and with a mean BMI of 28.2 kg/m² (range of 18.1 to 40.2 kg/m²). The mean trough for the unbound concentration of cefazolin was 5.02 μg/ml (range of 2.79 to 10.35 μg/ml). For 5 out of the 16 patients (31.25%) the targeted therapeutic goal of time above MIC (4 μg/ml) of 100% (T > MIC 100%) was not achieved. Seven corresponding pre and post CPB serum samples (A1-A7) were statistically analysed using the paired t-test. The results indicated no statistically significant differences between samples A1-A5 (p = 0.11, 0.34, 0.46, 0.32 and 0.98 respectively). There was a statistically significant difference between the samples A6 and A7 (p = 0.024 and 0.025), however, the clinical significance of these small differences is questionable. Conclusion: Surgical site infections not only result in significant morbidity and mortality but also lead to an increased financial burden to the country’s economy. This study has shown that potentially 31.25% of the patients undergoing cardiac surgery may have an increased risk of acquiring infections due to sub-optimal levels of prophylactic antibiotic during the surgery. In addition, the findings point towards no sequestration of cefazolin in the CPB circuits. / MT2017

Thesis (M. Med. Sc.)--University of Queensland, 2003. / Includes bibliographical references.

No description available.

No description available.