Research and development (R&D) covering diseases that disproportionately affect developing nations is grossly inadequate. In particular it has been noted over a long period that governments of countries with high tuberculosis (TB) disease burden under invest in TB R&D, despite having 40% of the world’s notified TB cases. For instance, South Africa’s (SA) annual expenditure on TB R&D, of US$1,2 million in 2012, is insignificant relative to its disease burden, of 1 003 per 100,000 population. New tools are required to stop TB; these tools require R&D investment. However a recent report has noted that for the first time in eight years, global spending on TB R&D decreased in 2012 compared with the previous year. This drop in R&D investment threatens to undermine the possibility of any future insights from TB research. The important question remains: how can public investment in TB R&D be stimulated or incentivised, especially within those countries of high prevalence and sizeable R&D budgets (such as India, SA, China and Russia)? In an attempt to answer such a question, this research followed a quantitative, case study methodology based on secondary data analysis of information from the World Health Organisation (WHO) and the SA National Strategic Plan (NSP) 2012-2016, looking at the costs associated with TB treatment in SA and identified areas of potential savings as a consequence of well directed R&D. For additional information on external funding and TB R&D investment, the study used the Organisation for Economic and Development (OECD) and Treatment Action Group (TAG) data. A return on investment estimation method for suitable R&D projects was then used to compute the optimal TB R&D investment range. The results of the research show that there are higher returns on the optimization of TB drug regimens versus new drug development. The argument proposed by this research is that further TB R&D expenditure can be justified from a purely economic return on investment consideration, considering that expenditure of public funds on TB treatment is high and significant savings can be made through improvements to the current drug regimen optimisation. This report will help policy makers in increasing public health R&D expenditure from present levels to those targets set by the World Health Organisation’s Consultative Expert Working Group (CEWG) and others. This return on investment will only be realised if public-funded R&D is focussed more directly on public health priorities. / Dissertation (MBA)--University of Pretoria, 2013. / lmgibs2014 / Gordon Institute of Business Science (GIBS) / MBA / Unrestricted

M.Com. (Business Management) / The study focuses on the return on marketing investment (ROMI) in the life insurance industry in South Africa. Although this is a growing industry, it is characterised by high competitiveness and similar product offerings from the different insurance providers. Therefore, in competing for the larger market share, the companies differentiate themselves by relying more on their unique strengths. They compete by promoting themselves and their products through various above-the-line and below-the-line marketing activities and campaigns in order to drive sales, build awareness, manage reputations, and to be top of mind to consumers. This study focuses on establishing whether these various marketing activities are measured to determine whether they contribute to the bottom line/ profit margins (basic purpose of ROMI) and to what extent. The ultimate goal is to establish whether ROMI is considered as being important to measure in the life insurance industry and whether spending on marketing activities does contribute to profit margins. A total of 16 recognised life insurance companies were identified and a sample size of seven companies selected. The sampling frame consisted of marketing managers, who happened to be heads of departments in this case. Structured interviews were conducted with these managers, and feedback was transcribed and analysed. Only marketing managers were interviewed as they are directly responsible for the marketing budget, and are accountable for marketing spending and the overall success of the department. It was identified in the study that in order to measure ROMI, it starts by being accountable for the marketing spending. The overall results of the study indicate that spending on marketing does contribute to profits margins and that ROMI is considered by the life insurance industry as important to measure. The study was limited only to the Gauteng province, thus it can be generalised to the life insurance companies in South Africa, but cannot be generalised to other insurance industries, e.g. short-term insurance, thus allowing for the possibility of a comparative study in the future, in addition to future studies listed in chapter 5.

Thesis (M.S.)--Massachusetts Institute of Technology, Alfred P. Sloan School of Management, 1980. / MICROFICHE COPY AVAILABLE IN ARCHIVES AND DEWEY. / Bibliography: leaves 84-85. / by David Glenn Naugle. / M.S.

No description available.

No description available.

by Ho King-sang. / Thesis (M.B.A.)--Chinese University of Hong Kong, 1981. / Bibliography: leaf 56.

A research report submitted in partial fulfilment of the requirements for the Degree of Master of Science in Engineering to the Graduate School of Engineering and the Built Environment of the Faculty of Engineering and the Built Environment University of Witwatersrand, Johannesburg March 2017 / Large-scale strategic ventures to build, add or improve an asset are being delivered in different sectors of industries around the world. These ventures resort to the intensive use of capital and resources and are mostly referred to as “capital projects”. Because of the large-scale nature of these capital projects, they have profound effects on their host countries, and their impact is larger than simply client and turnover, thereby influencing different areas of surrounding society. The nature and extent of this impact are (i) environmental, (ii) political, (iii) socio-economic and (iv) cultural. Amongst the socio-economic objectives is the capability to provide on-the-job training and create more job opportunities than would otherwise be possible. Recently there has been a surge of these capital projects in sub-Saharan Africa. However, sub-Saharan Africa continues to experience high levels of unemployment and a lack of skillsets. In an attempt to help address these problems, this research project evaluates employment creation and skills transfer during the delivery of capital projects in sub-Saharan Africa. Three case studies (researched between October 2013 and February 2015) were selected to collect data for this research project: (1) Nacala Corridor Railway Project (Malawi), (2) the Medupi Power Project (Republic of South Africa) and (3) the Gautrain Project Phases 1 and 2 (Republic of South Africa). The research findings illustrate clearly that there has been a significant positive shift in the creation of employment and skills transfer on capital projects. However, there are areas of weakness which have been identified even though the three case studies produced different results. In conclusion, the main weaknesses identified in all three projects are the lack of local high-level skilled employees and a clear indication that these capital projects are not being capitalised efficiently to develop skills amongst the locals, which are essential for such projects. Recommendations are provided for the sustainability of skills development and employment creation on capital projects. / MT 2017

A thesis submitted to the Faculty of Commerce, Law and Management, University of the Witwatersrand in fulfilment of the requirements for the degree of Doctor of Philosophy. Wits Business School 4 November 2016 / Sub-Saharan Africa faces severe infrastructure deficits including in power generation, water facilities, transportation, and telecommunications. These deficits compound the socio-economic challenges of the most impoverished region in the world. It is estimated that funding of US$ 90 billion per annum is required to address infrastructure deficiencies. Other developing regions including Asia, the Middle East, and South America, have with varying degrees of success utilised the project finance framework to address similar infrastructure deficiencies, and also develop other commercial ventures. Africa has lagged behind in this respect, and still accounts for less than 3% of international project finance flows. The ability to attract and access international and domestic project finance capital, and execute the underlying ventures is an important opportunity to address the challenges noted above. The study contributes to knowledge by deepening our understanding of project finance in South Africa, Mozambique, and Zimbabwe in the following ways. Firstly, it offers a model through which to monitor key contextual factors that influence the success, failure, and shaping of project and infrastructure ventures. Secondly, it interrogates the main capital structure theories including the static trade off and pecking order theories, and their applicability and relevance for project and infrastructure finance in the selected jurisdictions. It then compares capital structure theory with actual practice of capital structure formulation in the 7 cases studies investigated. This yields important insights as to the most important factors influencing capital structure in project finance in the three selected countries. In particular the constrained supply of capital is observed as the top factor determining capital structure. It further enhances our understanding of why ventures using project finance in these countries may have significantly lower leverage than other similar ventures in developed regions of the world. Thirdly, the study extracts key insights into how stakeholder interactions evolve in the projects by applying stakeholder agency theory to project sponsors, managers, contractors, state institutions, and community organisations. Collectively these insights should contribute to attracting increased capital to project finance in Sub-Saharan Africa, and arranging projects with greater prospects of operational success. / MT 2017