The main contribution of this thesis is the implementation of manufacturing constraints in shape and topology optimization. Fabrication limitations related to the casting process are formulated as mathematical constraints and introduced in the optimization algorithm. In addition, based on the same theoretical and modelization tools, we propose a novel formulation for multi-phase optimization problems, which can be extended to the optimization of structures with functionally-graded properties. A key ingredient for the mathematical formulation of most problems throughout our work is the notion of the signed distance function to a domain. This work is divided into three parts. The rst part is bibliographical and contains the necessary background material for the understanding of the thesis' main core. It includes the rst two chapters. Chapter 1 provides a synopsis of shape and topology optimization methods and emphasizes the combination of shape sensitivity analysis and the level-set method for tracking a shape's boundary. In Chapter 2 we give a short description of the casting process, from which all our manufacturing constraints derive. We explain how industrial designers account for these limitations and propose a strategy to incorporate them in shape and topology optimization algorithms. The second part is about the mathematical formulation of manufacturing constraints. It starts with Chapter 3, where the control of thickness is discussed. Based on the signed distance function, we formulate three constraints to ensure a maximum and minimm feature size, as well as a minimal distance between structural members. Then, in Chapter 4, we propose ways to handle molding direction constraints and combine them with thickness constraints. Finally, a thermal constraint coming from the solidi cation of cast parts is treated in Chapter 5 using several thermal models. Multi-phase optimization is discussed in the third part. The general problem of shape and topology optimization using multiple phases is presented in detail in Chapter 6. A "smoothed-interface" approach, based again on the signed distance function, is proposed to avoid numerical di culties related to classical "sharp-interface" problems and a shape derivative is calculated. An extension of this novel formulation to general types of material properties' gradation is shown in the Appendix A.