No / Causal inference is perhaps the most important form of reasoning in the sciences. A panoply of disciplines, ranging from epidemiology to biology, from econometrics to physics, make use of probability and statistics to infer causal relationships. The social and health sciences analyse population-level data using statistical methods to infer average causal relations. In diagnosis of disease, probabilistic statements are based on population-level causal knowledge combined with knowledge of a particular person¿s symptoms. For the physical sciences, the Salmon-Dowe account develops an analysis of causation based on the notion of process and interaction. In artificial intelligence, the development of graphical methods has leant impetus to a probabilistic analysis of causality. The biological sciences use probabilistic methods to look for evolutionary causes of the state of a current species and to look for genetic causal factors. This variegated situation raises at least two fundamental philosophical issues: about the relation between causality and probability, and about the interpretation of probability in causal analysis. In this book we bring philosophers and scientists together to discuss the relation between causality and probability, and the applications of these concepts within the sciences.

<p dir="ltr">Estimating causal effects from observational data has been challenging due to high-dimensional complex dataset and confounding biases. In this thesis, we try to tackle these issues by leveraging deep learning techniques, including sparse deep learning and stochastic neural networks, that have been developed in recent literature. </p><p dir="ltr">With the advancement of data science, the collection of increasingly complex datasets has become commonplace. In such datasets, the data dimension can be extremely high, and the underlying data generation process can be unknown and highly nonlinear. As a result, the task of making causal inference with high-dimensional complex data has become a fundamental problem in many disciplines, such as medicine, econometrics, and social science. However, the existing methods for causal inference are frequently developed under the assumption that the data dimension is low or that the underlying data generation process is linear or approximately linear. To address these challenges, chapter 3 proposes a novel causal inference approach for dealing with high-dimensional complex data. By using sparse deep learning techniques, the proposed approach can address both the high dimensionality and unknown data generation process in a coherent way. Furthermore, the proposed approach can also be used when missing values are present in the datasets. Extensive numerical studies indicate that the proposed approach outperforms existing ones. </p><p dir="ltr">One of the major challenges in causal inference with observational data is handling missing confounder. Latent variable modeling is a valid framework to address this challenge, but current approaches within the framework often suffer from consistency issues in causal effect estimation and are hard to extend to more complex application scenarios. To bridge this gap, in chapter 4, we propose a new latent variable modeling approach. It utilizes a stochastic neural network, where the latent variables are imputed as the outputs of hidden neurons using an adaptive stochastic gradient HMC algorithm. Causal inference is then conducted based on the imputed latent variables. Under mild conditions, the new approach provides a theoretical guarantee for the consistency of causal effect estimation. The new approach also serves as a versatile tool for modeling various causal relationships, leveraging the flexibility of the stochastic neural network in natural process modeling. We show that the new approach matches state-of-the-art performance on benchmarks for causal effect estimation and demonstrate its adaptability to proxy variable and multiple-cause scenarios.</p>

Injuries have emerged as one of the biggest public health issues of the 21th century. Yet, the causal effects of injury control strategies are often questioned due to a lack of randomized experiments. In this thesis, a set of quasi-experimental methods are applied and discussed in the light of causal inference theory and the type of data commonly available in injury surveillance systems. I begin by defining the interrupted time series design as a special case of the regression-discontinuity design, and the method is applied to two empirical cases. The first is a ban on the sale and production of non-reduced ignition propensity (RIP) cigarettes, and the second is a tightening of the licensing rules for mopeds. A two-way fixed effects model is then applied to a case with time-varying starting dates, attempting to identify the causal effects of municipality-provided home help services for the elderly. Lastly, the effect of the Swedish bicycle helmet law is evaluated using the comparative interrupted time series and synthetic control methods. The results from the empirical studies suggest that the stricter licensing rules and the bicycle helmet law were effective in reducing injury rates, while the home help services and RIP cigarette interventions have had limited or no impact on safety as measured by fatalities and hospital admissions. I conclude that identification of the impact of injury control interventions is possible using low cost means. However, the ability to infer causality varies greatly by empirical case and method, which highlights the important role of causal inference theory in applied intervention research. While existing methods can be used with data from injury surveillance systems, additional improvements and development of new estimators specifically tailored for injury data will likely further enhance the ability to draw causal conclusions in natural settings. Implications for future research and recommendations for practice are also discussed. / Injuries have emerged as one of the biggest public health issues of the 21th century. Yet, the causal effects of injury control strategies are rarely known due to a lack of randomized experiments. In this thesis, a set of quasi-experimental methods are discussed in the light of causal inference theory and the type of data commonly available in injury surveillance systems. I begin by defining the identifying assumptions of the interrupted time series design as a special case of the regression-discontinuity design, and the method is applied to two empirical cases. The first is a ban on the sale and production of non-fire safe cigarettes and the second is a tightening of the licensing rules for mopeds. A fixed effects panel regression analysis is then applied to a case with time-varying starting dates, attempting to identify the causal effects of municipality-provided home help services for the elderly. Lastly, the causal effect of the Swedish bicycle helmet law is evaluated using a comparative interrupted time series design and a synthetic control design. I conclude that credible identification of the impact of injury control interventions is possible using simple and cost-effective means. Implications for future research and recommendations for practice are discussed.

The theories of causality put forward by Pearl and the Spirtes-Glymour-Scheines group have entered the mainstream of statistical thinking. These theories show that under ideal conditions, causal relationships can be inferred from purely statistical observational data. Nancy Cartwright advances certain arguments against these causal inference algorithms: the well-known factory example argument against the Causal Markov condition and an argument against faithfulness. We point to the dependence of the first argument on undefined categories external to the technical apparatus of causal inference algorithms. We acknowledge the possible practical implication of her second argument, yet we maintain, with respect to both arguments, that this variety of causal inference, if not universal, is nonetheless eminently useful. Cartwright argues against assumptions that are essential not only to causal inference algorithms but to causal inference generally, even if, as she contends, they are not without exception and that the same is true of other, likewise essential, assumptions. We indicate that causal inference is an iterative process and that causal inference algorithms assist, rather than replace, that process as performed by human beings.

The theories of causality put forward by Pearl and the Spirtes-Glymour-Scheines group have entered the mainstream of statistical thinking. These theories show that under ideal conditions, causal relationships can be inferred from purely statistical observational data. Nancy Cartwright advances certain arguments against these causal inference algorithms: the well-known factory example argument against the Causal Markov condition and an argument against faithfulness. We point to the dependence of the first argument on undefined categories external to the technical apparatus of causal inference algorithms. We acknowledge the possible practical implication of her second argument, yet we maintain, with respect to both arguments, that this variety of causal inference, if not universal, is nonetheless eminently useful. Cartwright argues against assumptions that are essential not only to causal inference algorithms but to causal inference generally, even if, as she contends, they are not without exception and that the same is true of other, likewise essential, assumptions. We indicate that causal inference is an iterative process and that causal inference algorithms assist, rather than replace, that process as performed by human beings.

<p>This thesis examines causal inference related topics involving intermediate variables, and uses Bayesian methodologies to advance analysis capabilities in these areas. First, joint modeling of outcome variables with intermediate variables is considered in the context of birthweight and censored gestational age analyses. The proposed methodology provides improved inference capabilities for birthweight and gestational age, avoids post-treatment selection bias problems associated with conditional on gestational age analyses, and appropriately assesses the uncertainty associated with censored gestational age. Second, principal stratification methodology for settings where causal inference analysis requires appropriate adjustment of intermediate variables is extended to observational settings with binary treatments and binary intermediate variables. This is done by uncovering the structural pathways of unmeasured confounding affecting principal stratification analysis and directly incorporating them into a model based sensitivity analysis methodology. Demonstration focuses on a study of the efficacy of influenza vaccination in elderly populations. Third, flexibility, interpretability, and capability of principal stratification analyses for continuous intermediate variables are improved by replacing the current fully parametric methodologies with semiparametric Bayesian alternatives. This presentation is one of the first uses of nonparametric techniques in causal inference analysis,</p><p>and opens a connection between these two fields. Demonstration focuses on two studies, one involving a cholesterol reduction drug, and one examine the effect of physical activity on cardiovascular disease as it relates to body mass index.</p> / Dissertation

This thesis contributes to the research field of causal inference, where the effect of a treatment on an outcome is of interest is concerned. Many such effects cannot be estimated through randomised experiments. For example, the effect of higher education on future income needs to be estimated using observational data. In the estimation, assumptions are made to make individuals that get higher education comparable with those not getting higher education, to make the effect estimable. Another assumption often made in causal inference (both in randomised an nonrandomised studies) is that the treatment received by one individual has no effect on the outcome of others. If this assumption is not met, the meaning of the causal effect of the treatment may be unclear. In the first paper the effect of college choice on income is investigated using Swedish register data, by comparing graduates from old and new Swedish universities. A semiparametric method of estimation is used, thereby relaxing functional assumptions for the data. One assumption often made in causal inference in observational studies is that individuals in different treatment groups are comparable, given that a set of pretreatment variables have been adjusted for in the analysis. This so called unconfoundedness assumption is in principle not possible to test and, therefore, in the second paper we propose a Bayesian sensitivity analysis of the unconfoundedness assumption. This analysis is then performed on the results from the first paper. In the third paper of the thesis, we study profile likelihood as a tool for semiparametric estimation of a causal effect of a treatment. A semiparametric version of the Bayesian sensitivity analysis of the unconfoundedness assumption proposed in Paper II is also performed using profile likelihood. The last paper of the thesis is concerned with the estimation of direct and indirect causal effects of a treatment where interference between units is present, i.e., where the treatment of one individual affects the outcome of other individuals. We give unbiased estimators of these direct and indirect effects for situations where treatment probabilities vary between individuals. We also illustrate in a simulation study how direct and indirect causal effects can be estimated when treatment probabilities need to be estimated using background information on individuals.

This thesis aimed to apply the causal framework with potential outcomes to examine the causal effect of air temperature on reported violent crimes in Swedish municipalities. The Generalized Estimating Equations method was used on yearly, monthly and also July only data for the time period 2002-2014. One significant causal effect was established but the majority of the results pointed to there being no causal effect between air temperature and reported violent crimes.

abstract: Mediation analysis is used to investigate how an independent variable, X, is related to an outcome variable, Y, through a mediator variable, M (MacKinnon, 2008). If X represents a randomized intervention it is difficult to make a cause and effect inference regarding indirect effects without making no unmeasured confounding assumptions using the potential outcomes framework (Holland, 1988; MacKinnon, 2008; Robins & Greenland, 1992; VanderWeele, 2015), using longitudinal data to determine the temporal order of M and Y (MacKinnon, 2008), or both. The goals of this dissertation were to (1) define all indirect and direct effects in a three-wave longitudinal mediation model using the causal mediation formula (Pearl, 2012), (2) analytically compare traditional estimators (ANCOVA, difference score, and residualized change score) to the potential outcomes-defined indirect effects, and (3) use a Monte Carlo simulation to compare the performance of regression and potential outcomes-based methods for estimating longitudinal indirect effects and apply the methods to an empirical dataset. The results of the causal mediation formula revealed the potential outcomes definitions of indirect effects are equivalent to the product of coefficient estimators in a three-wave longitudinal mediation model with linear and additive relations. It was demonstrated with analytical comparisons that the ANCOVA, difference score, and residualized change score models’ estimates of two time-specific indirect effects differ as a function of the respective mediator-outcome relations at each time point. The traditional model that performed the best in terms of the evaluation criteria in the Monte Carlo study was the ANCOVA model and the potential outcomes model that performed the best in terms of the evaluation criteria was sequential G-estimation. Implications and future directions are discussed. / Dissertation/Thesis / Doctoral Dissertation Psychology 2018

In advanced democracies, many citizens abstain from participating in the political process. Does low and unequal voter turnout influence partisan election results or public policies? If so, how can participation be increased and how can the electorate become more representative of the greater population? / Government