Global ETD Search

1	Discovery of a Novel CCR5 Antagonist as an Effective Therapeutic Agent for Prostate Cancer Ahmed, Tasrif 30 July 2010 (has links) Previously, the CCR5 receptor was found to be a good target for treating prostate cancer (PCa). Dr. Yan Zhang’s laboratory designed several CCR5 antagonists, which were screened for their inhibitory effect on the growth and invasion of the M12, DU145 and PC-3 PCa cell lines. Primary in vitro screening showed one compound (Drug 17) significantly inhibited the proliferation of PCa cells at 1μM concentration, with a half-maximal inhibitory concentration of 237.68 nM. Further in vitro assays including a proliferation, cytotoxicity and invasion assay confirmed the inhibitory effect of drug 17. The physiological effect of drug 17 was tested by the Ware laboratory in vivo by subcutaneous injection of M12 cells into male, athymic nude mice. Tumor growth was slowed in mice receiving injections of drug 17 compared to sham injected controls. Thus, in vitro and in vivo assays suggest drug 17 might be an effective therapy to block PCa progression. prostate prostate cancer ccr5 ccl5 ccr5 antagonists PCa drug drug discovery tasrif ahmed chemokine receptor ligand Life Sciences Physiology