- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 1 to 10 of 103 (0.047 seconds)| 1 |
Regulation of proliferation in a cultured rat intestinal epithelial cell lineSmith, Roger David January 1991 (has links)
No description available.
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Investigation of G protein expression in human lymphoid cellsSharfe, Nigel January 1993 (has links)
No description available.
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Mutation analysis of the TSH receptor, GTP-binding proteins and protein kinase A in thyroid diseaseEsapa, Christopher Tarh January 1999 (has links)
No description available.
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Studies on the mechanism(s) of action of prolactin in Nb2 cellsAl-Sakkaf, Kaltoom A. January 1996 (has links)
No description available.
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The mitogenic activity of fibronectin fragmentsSavill, C. M. January 1985 (has links)
No description available.
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The relevance of heparin binding endothelial cell growth factors in angiogenesisOdedra, R. January 1987 (has links)
No description available.
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Tumour regrowth and cell compartment dynamics in a rat ?fibrosarcoma after cytotoxic therapyAffia, M. O. January 1984 (has links)
No description available.
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A gain-of-function screen to identify novel components of the insulin receptor signalling pathway and other growth regulators in Drosophila melanogasterFoulger, Rebecca E. January 2002 (has links)
No description available.
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The role of differentiation in the genesis of malignancyDonahoe, D. M. January 1988 (has links)
No description available.
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Protein turnover in serum-deprived mammalian cell culturesYin, Zhikang January 1985 (has links)
The aim of this project is to test the hypothesis that the rate of turnover of newly synthesized proteins plays a major part in the regulation of cell growth. Normal and transformed cells have been used to compare their responses to serum levels. When the cells are cultured in 0.2% serum medium, increase of cell number is slower than in normal cultures. Cell volume is reduced, while cell mass may be maintained or decreased depending on the rate of protein accumulation and cell proliferation, so unbalanced growth may occur in certain circumstances. During serum deprivation, accumulation of newly synthesized proteins slows down due to both aspects of reduced protein synthesis rate and increased degradation of proteins, mainly, medium- and long-lived proteins. After serum restoration, their rate of protein synthesis increased, and the rate of long-lived protein degradation was reduced to a lower level than in cells kept continuously in 10&37 serum, indicating that medium- and long-lived proteins are more important than short-lived proteins in the regulation of cell growth. After serum step-down, untransformed 3T3 cells did not enter a truly G<sub>0</sub> state, but showed a very slow increase in cell number; transformed 3T3 and HeLa cells showed 'unbalanced growth', i.e. cell number increased faster than proteins accumulated. Serum deprivation quickly and substantially affected growth of untransformed 3T3 cells, but transformed 3T3 and HeLa cells retain their growth rate higher than that of untransformed 3T3 cells. Contrary to general belief, the transformed 3T3 cells and HeLa cells were quite responsive in many respects to serum withdrawal. This fact indicates that stimulating growth by 'autocrine' mechanism is limited. Investigation of the pathways of protein degration and rate of RNA synthesis were undertaken. Attention was paid to basic problems associated with the serum deprivation, and the serum-deprived cell culture system as a model or paradigm for studies of this nature is discussed.
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