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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Search results

Showing 1 to 10 of 29 (0.069 seconds)
1

Proteomic insights into mhc class i antigen processing and presentation

Goodenough, Elliot 31 May 2014 (has links)
<p> The classical model of MHC class I antigen processing prescribes a critical role for the ubiquitin-proteasome system in generating peptides to display for CD8+ T cell surveillance. However, multiple exceptions to this pathway have been described. Using large-scale proteomic methods as well as model experiments, we explore 1) the non-proteasomal enzymes responsible for generating or destroying an influenza virus epitope; 2) the role of ubiquitin-independent antigen processing in shaping the MHC class I peptidome; and 3) the contribution to the MHC class I peptide repertoire of aminoglycoside-induced translational readthrough of stop codons. Our findings indicate a significant role for non-classical MHC class I antigen processing. This includes extra-proteasomal proteases we identify as destroying the influenza epitope NP147-155, as well as an impact from ubiquitin-independent pathways that challenges the centrality of the ubiquitin-proteasome system. Additionally, we demonstrate that the non-standard translational events induced by gentamicin can reveal cryptic MHC class I epitopes, with implications for autoimmunity. These observations suggest a substantial contribution from processes that operate outside of the classically described pathways of MHC class I antigen processing.</p>
2

Defining the lumenal environment of the maturing phagosome in macrophages and its modulation in response to immune and pathogen-derived stimuli

Yates, Robin M. Unknown Date (has links)
Thesis (Ph.D.)--Cornell University, 2007. / (UMI)AAI3254638. Source: Dissertation Abstracts International, Volume: 68-03, Section: B, page: 1400. Adviser: David Russell.
3

Chitin in allergic immunity.

Reese, Tiffany A. January 2007 (has links)
Thesis (Ph.D.)--University of California, San Francisco, 2007. / Source: Dissertation Abstracts International, Volume: 68-11, Section: B, page: 7235. Adviser: R. M. Locksley.
4

Septin function in T lymphocyte crawling and structural integrity.

Tooley, Aaron J. January 2007 (has links)
Thesis (Ph.D.)--University of California, San Francisco, 2007. / Source: Dissertation Abstracts International, Volume: 68-04, Section: B, page: 2239. Adviser: Matthew F. Krummel. Includes supplementary digital materials.
5

The roles of Bim-dependent apoptosis in controlling the responses of CD4+ T helper lymphocytes.

Barron, Luke. January 2007 (has links)
Thesis (Ph.D.)--University of California, San Francisco, 2007. / Source: Dissertation Abstracts International, Volume: 68-04, Section: B, page: 2232. Adviser: Abul K. Abbas.
6

Plasma membrane dynamics and pattern formation during T cell activation.

Douglass, Adam D. Unknown Date (has links)
Thesis (Ph.D.)--University of California, San Francisco, 2006. / Source: Dissertation Abstracts International, Volume: 67-08, Section: B, page: 4195. Adviser: Ronald D. Vale.
7

The role of GATA-3 in the mammary gland and in breast cancer.

Kouros-Mehr, Hosein. Unknown Date (has links)
Thesis (Ph.D.)--University of California, San Francisco, 2006. / Source: Dissertation Abstracts International, Volume: 67-08, Section: B, page: 4197. Adviser: Zena Werb.
8

B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency.

Gupta, Vikas. January 2007 (has links)
Thesis (Ph.D.)--University of California, San Francisco, 2007. / Source: Dissertation Abstracts International, Volume: 68-07, Section: B, page: 4374. Adviser: Arthur Weiss.
9

Modulation of BLT1 expression in human NK cells by selected cytokines.

El-Maghraby, Nermine Mostafa. Unknown Date (has links)
Thèse (M.Sc.)--Université de Sherbrooke (Canada), 2007. / Titre de l'écran-titre (visionné le 1 février 2007). In ProQuest dissertations and theses. Publié aussi en version papier.
10

Understanding the early events in breast carcinogenesis by inactivating p16INK4a in primary human mammary epithelial cells.

Pickering, Curtis Reid. January 2008 (has links)
Thesis (Ph.D.)--University of California, San Francisco, 2008. / Source: Dissertation Abstracts International, Volume: 69-09, Section: B, page: 5334. Adviser: Thea D. Tlsty.

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