Recent research in bioinformatics has presented multiple cell type identification meth- dologies using single cell RNA sequence data (scRNA-seq). However, a consensus on which cell typing methodology consistently demonstrates superior performance remains absent. Additionally, very few studies approach cell type identification through a semi- supervised learning study, whereby the information in unlabeled data is leveraged to train an enhanced classifier. This paper presents cell annotation methodologies through self- learning and graph-based semi-supervised learning, in both raw count scRNA-seq data as well as in a latent embedding. I find that a self-learning framework enhances perfor- mance compared to a solely supervised learning classifier. Additionally, modelling on the latent data representations consistently outperforms modelling on the original data. The results show an overall accuracy of 96.12%, whereas additional models achieve an average precision rate of 95.12% and an average recall rate of 94.40%. The semi-supervised learn- ing approaches in this thesis compare favourable to scANVI in terms of accuracy, average precision rate, average recall rate and average f1-score. Moreover, results for alternative scenarios, in which cell types among training and test data do not perfectly overlap, are reported in this thesis.