Abstract Central venous access devices (CVADs) have become essential interventions for pediatric patients. However, their use is associated with serious complications. The most common and potentially preventable complication is catheter related blood steam infections (CRBSIs). Despite the implementation of interventions that have been shown to decrease their risk, CRBSIs still occur. Pediatric nurses were surveyed regarding their knowledge and application of recommended CVAD care practices, and their perspectives on possible factors that could contribute to the incidence of CRBSIs. Donabedian’s (1966) Structure-Process-Outcome Model guided the study. A cross-sectional, descriptive and exploratory mixed-methods survey design was used. The convenience sample consisted of 93 pediatric nurses. Findings indicate areas of concern related to adherence to CVAD care guidelines and situations that could interfere with the provision of recommended CVAD care. The primary factor identified was the use of improper technique by members of the healthcare team and the patients’ families.