General uncertainty analysis was used to evaluate the performance of a Rocket-Based Combined Cycle (RBCC) engine system. To estimate the uncertainties of test results, uncertainties of basic measurements such as temperature, pressure, mass flow rate, and thrust were determined. The desired test results of interest included specific impulse and characteristic velocity. Various possible test facilities were reviewed to obtain background information and example test run conditions. Based on the test run conditions, five methods of determining specific impulse were evaluated. Also, theoretical and actual characteristic velocities were analyzed to evaluate C* efficiency. Initially, general uncertainty analyses were completed relative to 1% accuracy for each measured variable. Then, cases were run using more realistic uncertainty estimates. The relative contributions of the different variables? uncertainties to the overall uncertainty of the selected performance parameters were also calculated. This process helps to identify the critical measurements from an uncertainty standpoint and can be a significant guide in the cost effective use of resources to reduce the test uncertainty.