In general, the characteristics of stone are two: high regenerative thermal activity and low cost. In this study, isopropyl alcohol (IPA) was oxidized by metallic catalysts with stones as carriers. To discover the best removal efficiency of isopropyl alcohol, different catalysts with different ratios of metal (these metals were copper, manganese, and cobalt) and different loading (loading meant the ratio of the weight of metal to the weight of stone) were made. Moreover, others parameters such as different inlet concentration of IPA, inlet concentration of oxygen, space velocity, reaction temperature, and long-term test were also discussed. Finally, two kinetic models were introduced to prove the catalytic oxidation mechanism of IPA. The experimental results showed that the most effective catalyst is copper-cobalt catalyst, which ratio of metals is 6: 4 and loading is 10%. With this kind of catalyst, the optimal operational parameters could be easily found, and they were as follows: the inlet concentration of IPA was 1500 ppm, space velocity was 13500 hr-1, and reaction temperature was 350¢J. It was noticed that the conversion of IPA was all up to 95% in these conditions. In conclusion, the experimental results also indicated that conversion was increased with reaction temperature, inlet concentration of IPA and inlet concentration of oxygen increasing. On the contrary, the conversion was decreased as space velocity was increased. Besides, after long-term test of catalyst, the results showed that the performance of the catalyst acted still fairly well in oxidation. To realize the physical properties of catalysts, some analytic instruments such as SEM, EDS, EA, XRD were used. These analytic results could also tell us the difference between fresh and aged catalysts. Two kinetic models, Power rate law Model and Mars-Van Krevelen Model, were used to fit the kinetic mechanism of the decomposition of IPA. The fitting result was that Power rate law Model was rather suitable to describe the catalytic decomposition of IPA in the operational conditions in this work, and the reaction order was nearly first order.