Low-dose aspirin therapy in dogs inconsistently inhibits platelet function, termed ‘aspirin resistance’. There are no established diagnostic tests that can predict aspirin resistance in dogs prior to therapy. Platelet function was evaluated in healthy dogs prior to and during low-dose aspirin therapy using turbidimetric and impedance aggregometry, PFA-100, and urine 11-dehydro-thromboxane-B2 concentration. Following a washout, platelet-rich plasma from the dogs was incubated with aspirin and evaluated via turbidimetric aggregometry. After aspirin, the majority of dogs were classified as ‘aspirin responders’ with 81% responding after 7 days. Platelet dysfunction was not consistent in all dogs at all times. Compared to turbidimetric, impedance and PFA-100 results were inconsistent when run concurrently, suggesting turbidimetric is the preferred technique. There was poor agreement between in vitro aspirin incubation and all other tests. Unlike in people, platelet function in dogs is consistently inhibited by aspirin incubation, making this a poor technique for predicting aspirin resistance.

This thesis is focused on design and implementation of TSQL2 language interpreter for SQL. It briefly introduces temporal database and language TSQL2. Currently available implementations of temporal database systems are introduced and their practical usability for temporal data is reviewed. Main part of this thesis covers design and implementation of TSQL2 interpreter. A working TSQL2 interpreter implemented in Java as JDBC adapter is the result of this work.