During the past forty years, Oregon voters have approved only two tax proposals; both taxes on cigarettes. The subject of this study is the campaign carried out by proponents of H.B. 3064 to pass the most recent Oregon tax referendum measure. Central to the questions asked in the investigation of the 1972 cigarette tax campaign was why the outcome of this proposal was successful. The thesis hypothesizes that the critical variable was the involvement of major socio-economic interest groups in formulating and disseminating persuasive campaign messages. The rationale for entering into such a study was the shortage of information on campaigns which focus not only on the effects of the "new politics" on the electorate, but which fill in details of significance to the historical setting within which the campaign takes place. Further, there is an apparent shortage of information on state-wide referendum campaigns which describe the campaign setting, the structure of the decision-making organization directing the campaign effort, and the voters reaction to campaign strategies. For these reasons two research methods were utilized for the descriptive case study: a field investigation and a two-part opinion survey. The former traced the historical-political situation in Oregon, action taken by the 1971 legislative assembly to correct the state budgetary dilemma, the mobilization of public and private individuals following the successful referral drive to place the cigarette tax on the ballot, and campaign strategies carried out during the 40 day period prior to the special election. By reviewing all available news reports and interviewing those persons active in the campaign, the field investigation revealed that the state was indeed threatened by budgetary crisis and that the proposed tax was the only immediately available solution. An alternative source would have required another special session, another 90 day waiting period, and the threat of another referendum. Without the tax, state agencies depending for support on revenue coming from the General Fund would face a two percent cut in funds for the 1972-73 fiscal year. It was also found in the field investigation that the cigarette tax had support from legislative leaders of both political parties; a collection of large permanent interest groups; and an array of state officials and private citizens with pocket-book interest in passing the ballot measure. Persuasive appeals developed by the involved groups focused on the fiscal impact of a tax defeat on these and other special economic groups in Oregon. Results of the second research method, the voter-leadership survey, indicated that the voters surveyed were generally accurate in assessing the participation of interest groups and were influenced by those groups most visible and state officials most vocal. It also revealed that while the voters professed to being influenced by certain groups or individuals, the reasons they gave for their vote choice were not those emphasized by the influence sources. The leadership survey found that interest group leaders were somewhat more accurate than legislators in ascribing motives to the choices voters made, but that there was a significant discrepancy between opinions of voters and opinions of the state leadership relevant to the reasons people voted as they did. As to the central question of this thesis, the investigation did confirm the proposition that interest groups made the difference in the success of the 1972 cigarette tax measure. Interest groups were effective, chiefly because of the many roles they performed in each phase of the campaign: as initiators of campaign activity, as legitimizers, as fund raisers, and as channel sources for disseminating persuasive messages to both their own members and to the general public. The study strongly suggests that it was the mediating activity of state and local influential, through the mechanisms of special interest pressure and cause groups which provided the critical margin in the vote outcome.

Background: Electronic nicotine products (ENPs) such as e-cigarettes have emerged as the most commonly used tobacco products among middle and high school students in the United States (U.S.). In 2019, almost 1 in 10 and 1 in 4 middle and high school students used e-cigarettes, respectively. Although familial relations and access to ENPs continue to play a major role in the uptake of e-cigarettes among adolescents, little is known about the role of social media in this phenomenon. Therefore, this study aimed to assess the role of social media in the uptake of e-cigarettes among students in Appalachian Tennessee. Methods: In March 2019, data involving high school students in an Appalachian Regional Commission (ARC)-designated distressed county in Appalachian Tennessee were collected (N=399). We ascertained the study’s outcomes (current e-cigarette use), the exposure (use of social media and the type of social media used to discuss e-cigarette) and covariates using validated questions. Descriptive statistics, bi-variate and multi-variable analyses were performed. The Odds Ratios (ORs), confidence intervals (CI), and the significance level (p ≤ 0.05) have been reported. Results: About 15.5% of the population were current e-cigarette users, with 9.8% of them ever discussed electronic cigarettes/JUUL on social media, more commonly with snap-chat (8.33%) and Instagram (4.31%). Use of social media (OR = 0.56, CI = 0.37 - 0.83, p = 0.0042) and type of social media used (OR = 0.80, CI = 0.65 - 0.99, p =0.0375) were significantly associated with decreased number of days of e-cigarette use in the last 30 days, after controlling for the covariates. Conclusion: The use of social media was associated with current e-cigarettes users. As such, there is need for more in-depth examination of social media contents as it relates to ENPs, to understand the mechanism of reduced ENP use among school-going youths in rural Appalachia.

Objectives: To assess labelling accuracy for low nicotine concentration e‐cigarette liquids. Methods: Nicotine concentration in twelve e‐liquids, available in 3 and 6 mg/ml strengths, was assayed (5 replicates each) using liquid chromatography–tandem mass spectrometry. Key findings: Average nominal concentrations of nicotine were lower than reported in 23/24 products tested, with 2/12 products labelled 3 mg/ml, and 3/12 of the 6 mg/ml products showing statistically significant differences from controls. Conclusions: Despite the emergence of a global regulatory environment for e‐cigarettes, inaccuracies still exist in nicotine concentration labelling, which may affect user habits and reliability of products used in smoking cessation.

No description available.

Current methods for the risk assessment of environmental exposures commonly involve questionnaires, stationary monitoring, and personal air sampling. However, as these approaches do not capture the body's internal response, they lend minimal understanding to the biologic consequence of exposure. In order to address the unmet need of connecting external exposure measurements with signatures of internal exposure, this thesis examines the overarching hypothesis that transcriptomic changes in the human airway epithelium can serve as indicators of physiologic responses to inhaled pollutants. This is an extension of previous work that has demonstrated an airway ''field of injury'' effect where cigarette smoke exposure alters gene-expression in epithelial cells lining the respiratory tract. Specifically, I examine transcriptomic changes and the biologic responses associated with exposure to the following pollutants: environmental tobacco smoke (Aim 1), household air pollution from smoky coal combustion (Aim 2), and electronic cigarette vapor (Aim 3). First, I performed whole-genome transcriptional profiling of the nasal epithelium in children and adults and detected gene-expression changes associated with exposure to environmental tobacco smoke. Next, I employed similar approaches to detect a signature of coal smoke exposure in the buccal epithelium of healthy, non-smoking females exposed to household air pollution Xuanwei, China. The findings from these studies suggest that upper airway gene-expression can reflect the host response to prolific sources of environmental exposures that are major risk factors for chronic lung disease. Lastly, I examine the cellular and physiologic consequences of electronic cigarette (ECIG) aerosol exposure by analyzing transcriptomic profiles of human bronchial epithelial cells that have either been (1) differentiated and exposed in vitro or (2) acquired via bronchoscopy from the airway epithelium of ECIG users. The studies detailed in this dissertation offer valuable insight that will accelerate the efforts to evaluate the health effects of both well-established and emerging types of inhaled exposures in large-scale population studies. Furthermore, the transcriptomic strategies woven throughout the following chapters push for a novel assessment paradigm that may enable the public health community to rapidly characterize the physiologic host response to inhalation exposures of different sources, and to evaluate the biologic consequences of exposure-reduction initiatives. / 2017-05-01T00:00:00Z

The human body encounters a number of chemical exposures on a daily basis, which may have short- or long-term health implications. Previously it has been demonstrated that the entire respiratory tract of an individual reacts to exposures like tobacco smoke in a similar manner, and that common molecular changes can be measured in airway epithelium. I propose that cataloguing the exposure of airway epithelial cells to tobacco cigarette (TCIG) smoke and its constituents, electronic cigarette (ECIG) aerosol and other drugs and small molecules can significantly increase the understanding of chemical exposure and identify common gene expression alterations. First, I determined the molecular impact of ECIG aerosol exposure on human airway epithelium in vitro, including alterations in genes related to xenobiotic metabolism, oxidative stress, and ciliated cells. These changes were generally less pronounced than the effects of TCIG exposure, and were more pronounced in ECIG products containing nicotine than those without nicotine. Furthermore, gene expression differences observed in vitro were concordant with differences observed in airway epithelium collected from ECIG users. Second, I examined the impact of TCIG exposure and TCIG constituents on premalignant airway cells, to better understand the progression or regression of precancerous lesions. These data could also identify the constituents of TCIGs and the precancerous mutations that increase the risk for malignancy. Third, in an effort to build a high-throughput methodology for chemical exposures, I exposed primary lung cell lines to small molecule therapeutics and identified lung-specific and lung cell-type-specific effects of exposure, suggesting that profiling additional cell lines would further inform airway gene expression in response to exposure and that organ-specific exposure profiling may provide valuable insight into drug discovery for common diseases. Overall, transcriptomic profiles from the airway epithelium reflect exposure to various inhaled and chemical perturbations. These gene expression profiles indicate common changes across a multitude of airway exposures as well as unique alterations specific to a given perturbation. Gene expression profiling can therefore be used to detail the potential response to a compendium of chemical exposures including those that are either well-established or potential risk factors for chronic lung diseases. / 2019-07-09T00:00:00Z

No description available.

Le cancer du poumon chez la femme était une maladie rare au début du XXème siècle. Son incidence a fortement augmenté durant ces vingt dernières années dans les pays développés et particulièrement en France du fait de l’augmentation de la consommation de cigarettes dans la population féminine. L’étude des risques de cancer du poumon liés à la consommation de cigarettes des femmes a soulevé la question d’une éventuelle plus grande susceptibilité des femmes vis-à-vis du tabac dans la survenue du cancer du poumon par rapport aux hommes. Les résultats des études épidémiologiques sur le sujet sont divergents et l’hypothèse selon laquelle les hormones joueraient un rôle dans cette plus grande susceptibilité des femmes a été proposée pour expliquer ces différences. Objectifs : Les objectifs de cette thèse sont de donner des estimations récentes du risque de cancer du poumon chez la femme associé à la consommation de cigarettes en France, de comparer le risque de cancer du poumon chez les femmes et chez les hommes et d’étudier le rôle des hormones dans le risque de cancer du poumon.Matériel et méthodes : L’étude de la consommation de cigarettes chez les femmes et la comparaison des risques de cancer du poumon associé à cette consommation a été réalisée à partir des données de l’étude ICARE. Les cas de cancer du poumon ont été identifiés dans 10 départements incluant un registre général de cancer. Au total, 2276 cas de cancer du poumon chez les hommes et 2780 témoins ont été inclus ainsi que 650 cas de cancers du poumon féminins et 775 témoins. Les témoins étaient issus de la population générale, avec une distribution âge et sexe conforme à celle des cas et une répartition par statut socioéconomique conforme à celle des départements dont sont issus les cas. L’analyse du rôle des hormones et des facteurs reproductifs sur le risque du cancer du poumon a été menée par une analyse poolée, réunissant 9 études internationales. Cette étude a été réalisée dans le cadre du consortium ILCCO. Au total, 4547 cas et 4176 témoins ont été inclus dans l’analyse.Résultats : Notre étude a montré que le risque de cancer du poumon associé à la consommation de cigarettes est 8 fois plus élevé chez les femmes fumeuses par rapport aux non fumeuses en France. La quantité moyenne fumée, la durée totale de consommation et le délai depuis l’arrêt sont les 3 principales caractéristiques de consommation qui modulent le risque de cancer du poumon. La fraction de risque attribuable à la consommation de cigarettes est estimée à 55% [47 %-63 %]. La comparaison du risque de cancer du poumon entre les hommes et les femmes est très influencée par la présence des non fumeurs. . Bien que nous n’ayons pas trouvé de différence de risque de cancer du poumon entre les hommes et les femmes fumeurs lorsque l’on considère tous les types histologiques réunis, nous avons constaté que les femmes relativement aux hommes étaient plus à risque de cancer à petites cellules et de cancer épidermoïde, qui sont les types histologiques les plus liés à la consommation de cigarettes. Concernant l’étude sur le rôle des hormones dans la survenue de cancer du poumon, nos résultats montrent que plus l’âge à la ménopause est tardif et plus la durée des cycles menstruels est longue, moins le risque de cancer du poumon est important. Nous avons également montré que l’ovariectomie était associée positivement avec le risque de cancer du poumon. Conclusion : Nos résultats semblent indiquer que les femmes fumeuses sont peut-être plus à risque de développer un carcinome à petites cellules ou un cancer épidermoïde par rapport aux hommes fumeurs. L’étude sur les facteurs hormonaux a montré une association négative avec l’exposition prolongée aux hormones, qui n’est pas très cohérente avec un risque de cancer du poumon associé au tabac plus important chez les femmes que chez les hommes. / The incidence of female lung cancer in developed countries has been increasing since 1950 and particularly in France where the cigarettes consumption has also increased. Since 1980, a growing number of epidemiological surveys have pinpointed the risk of female lung cancer related to smoking. Consecutively, a debate on gender differences in lung cancer risk has appeared, but still in progress nowadays. The reproductive factors could explain these differences. In order to have recent and reliable data on the association between cigarettes smoking and the risk of lung cancer in women and to compare the lung cancer risk associated with smoking exposure between genders, we analyzed the data of a French population-based case-control study, ICARE. The role of the reproductive factors in lung cancer was analyzed pooling, 9 international epidemiological studies included in ILCCO consortium.The ICARE study included 2276 male and 650 female cases and 2780 male and 775 female controls. Lifetime smoking exposure was represented by the comprehensive smoking index (CSI) which combines total duration of smoking, the mean intensity and the time since cessation. The pooled analysis of the reproductive factors included a total of 4547 cases and 4176 controls were included.Among the ever smokers, the relative risk of lung cancer was similar among men and women after adjustments for age, département, education, BMI, occupational exposure and chronic bronchitis. However, we found that women have a 2-fold greater risk than men of developing either small cell carcinomas or squamous cell carcinomas. Alternatively, the association was similar between men and women for the adenocarcinomas. As regard the reproductive factors, we found that longer is the age at menopause, lower is the lung cancer risk. Moreover, longer is the duration of cycle, lower is the lung cancer risk. The ovariectomy is also associated with an increasing risk of lung cancer.Our findings suggest that women might be more susceptible than men to develop small cell carcinoma or squamous cell carcinoma in response to the carcinogenic effect of cigarettes smoking. The analysis on the reproductive factors showed an inverse association between hormonal exposure and lung cancer indicating a likely complex relationship between the two factors.

This thesis is based on the question, whether a taxation have an effect on consumption of cigarettes. At the first there was needed to find factors which affect the cigarettes consumption. These factors are socioeconomic status of the population or using regulatory politics for tobacco products. Analysis is based on estimation econometrics model of regression analysis on panel data set. The panel data set consist from information about member states of European union for years 2003 to 2015. The goal of the thesis is to find an answer whether the tax policy of member states in according to taxation of cigarettes is effective. It means whether taxation of cigarette have an impact on cigarettes consumption. The analysis show that the explanatory variable for taxation is statistically inefficient. That say that the level of taxation does not affect the cigarettes consumption.

Indiana University-Purdue University Indianapolis (IUPUI) / Smoke-free legislation in the United States has unintentionally resulted in a decline in alcohol consumption. However, more recently electronic-cigarettes (e-cigs), which are associated with alcohol use, are reportedly being used to circumvent smoking bans. The present study surveyed community dwelling individuals in the United States reporting e-cigs may be used where they drink (N=365, mean age=33.63, SD=9.91, 53.2% female, 78.9% Caucasian) to examine how e-cig use and alcohol consumption varies by the presence of smoking prohibition where one consumes alcohol. Results indicated that smoking prohibition was associated with a greater likelihood of being an ecig user than a cigarette user (OR=3.40, p<.001) and a higher likelihood of being an e-cig user than a dual user (OR=3.37, p<.001). Smoking prohibition was not associated with AUDIT scores (B=-0.06, p=.21), total drinks (B=-.07, p=.19), or average drinks (B=-0.02, p=.76). E-cig users reported significantly fewer average drinks when smoking is prohibited as compared to allowed, t(55)=3.26, p=.002. Overall, current results suggest smoking prohibition is associated with a greater likelihood of being an e-cig user; however, smoking prohibitions are not associated with alcohol consumption and related problems in the current participants, who all reported being able to use e-cigs where they consume alcohol. Future research should address potential conceptual, methodological, and sample limitations in order to better discern this relationship, as this line of research could have important implications for e-cig policy and alcohol use treatment