Esta tesis está basada en un ensayo clínico, simple-ciego y no aleatorizado, realizado en el servicio de Cirugía Oral y Maxilofacial del Hospital Nacional Hipólito Unanue, cuyo objetivo fue determinar si la terapia con diclofenaco más vitaminas B es superior a la terapia con sólo diclofenaco en pacientes sometidos a cirugía electiva de tercera molar inferior. Se formaron 2 grupos, un grupo recibió diclofenaco más vitaminas B y el otro diclofenaco solo. La variable principal fue la intensidad de dolor medida luego de 1, 3, 6, 9, 12 y 24 horas de finalizada la cirugía mediante una escala gráfica verbal del 0-100; las variables secundarias fueron el tiempo para analgesia de rescate y la cantidad de analgésicos consumidos en el postoperatorio. Treinta pacientes completaron el estudio, quince de ellos recibieron diclofenaco (75 mg) más una mezcla de vitaminas B (B1: 100 mg, B6: 100 mg y B12: 10 mg) y los otros quince solamente diclofenaco (75 mg). Ambas terapias fueron administradas por vía intramuscular al finalizar la cirugía. Los resultados mostraron que la adición de vitaminas B al diclofenaco mejoró la eficacia analgésica del diclofenaco en la variable principal pero no de manera estadísticamente significativa (p > 0.05). Palabras clave: diclofenaco - vitaminas b - cirugía dental - tercera molar impactada / --- This thesis is based on a single-blind, non-randomized clinical trial which took place in the oral and maxillofacial surgery service of the Hipólito Unanue National Hospital, of which objective was to determine if the therapy using diclofenac plus B vitamins is better than the therapy using only diclofenac in patients subjected to elective surgery of inferior third molar. Two groups were formed, a group received diclofenac plus B vitamins and the other group received diclofenac only. The main variable was the intensity of pain measured after 1, 3, 6, 9, 12 and 24 hours the surgery had finished using a verbal graphic scale (0-100); the secondary variables were the time for rescue analgesics consumption and the amount of rescue analgesics taken in the postoperative period. Thirty patients completed the study, fifteen of them received diclofenac (75 mg) plus B vitamins (B1: 100 mg, B6: 100 mg and B12: 10 mg) and other fifteen patients received only diclofenac (75 mg). Both therapies were administered by intramuscular route once the surgery was finished. The results showed that by adding B vitamins to diclofenac improved the analgesic effectiveness of diclofenac in the main variable but there were no statistically significant differences. Keywords: diclofenac – b vitamins – dental surgery – impacted third molar / Tesis