Wastewater treatment plants (WWTPs) face increasingly stringent effluent quality constraints as a result of rising environmental concerns. Efficient operation of the secondary clarification process is essential to be able to meet these strict regulations. Treatment plants can benefit greatly from making better use of available resources through improved automation and implementing more process systems engineering techniques to enhance plant performance. As such, the primary objective of this research is to utilize data-driven modeling techniques to obtain a representative model of a simplified secondary clarification unit in a WWTP. First, a deterministic subspace-based identification approach is used to estimate a linear state-space model of the secondary clarification process that can accurately predict process dynamics, with the ultimate objective of motivating the use of the subspace model in a model predictive control (MPC) framework for closed-loop control of the clarification process. To this end, a low-order subspace model which relates a set of typical measured outputs from a secondary clarifier to a set of typical inputs is identified and subsequently validated on simulated data obtained via Hydromantis's WWTP simulation software, GPS-X. Results illustrate that the subspace model is able to approximate the nonlinear process behaviour well and can effectively predict the dynamic output trajectory for various candidate input profiles, thus establishing its candidacy for use in MPC. Subsequently, a framework for forecasting the occurrence of sludge bulking--and consequently clarification failure--based on an engineered interaction variable that aims to capture the relationship between key input variables is proposed. Partial least squares discriminant analysis (PLS-DA) is used to discriminate between process conditions associated with clarification failure versus effective clarification. Preliminary results show that PLS-DA models augmented with the interaction variable demonstrate improved predictions and higher classification accuracy. / Thesis / Master of Applied Science (MASc)