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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Studying the Predictors of Clinical Heterogeneity in Boys with Severe Hemophilia A

Hang, Marissa Xi 20 January 2010 (has links)
Persons with severe hemophilia A exhibit significant variations in clinical phenotype; approximately 10% are milder bleeders. This study explored factors that might contribute to this inter-patient heterogeneity. Using a multi-center prospective study following boys with severe hemophilia A on a tailored primary prophylaxis regimen, age at first joint bleed, body mass index, protocol adherence and family activity level were modeled on the age at escalation from once-weekly to twice-weekly and alternate day infusions. Escalation, based on bleeding frequency, served as a surrogate marker of bleeding severity. We also assessed the roles of clinical and hemostatic parameters in predicting age at first joint bleed using a cross-sectional study. Results suggest that a delayed first joint bleed indicates later escalation (milder bleeding pattern) and that a longer lag time is associated with an earlier onset of joint bleeding. Larger studies are needed to definitively identify predictors of clinical heterogeneity in these patients.
2

Studying the Predictors of Clinical Heterogeneity in Boys with Severe Hemophilia A

Hang, Marissa Xi 20 January 2010 (has links)
Persons with severe hemophilia A exhibit significant variations in clinical phenotype; approximately 10% are milder bleeders. This study explored factors that might contribute to this inter-patient heterogeneity. Using a multi-center prospective study following boys with severe hemophilia A on a tailored primary prophylaxis regimen, age at first joint bleed, body mass index, protocol adherence and family activity level were modeled on the age at escalation from once-weekly to twice-weekly and alternate day infusions. Escalation, based on bleeding frequency, served as a surrogate marker of bleeding severity. We also assessed the roles of clinical and hemostatic parameters in predicting age at first joint bleed using a cross-sectional study. Results suggest that a delayed first joint bleed indicates later escalation (milder bleeding pattern) and that a longer lag time is associated with an earlier onset of joint bleeding. Larger studies are needed to definitively identify predictors of clinical heterogeneity in these patients.

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