BACKGROUND Because the medical envirement continously progresses, all the people working in hospital or health department are concerned in the health issues. Although the Intergration Delivery System was used for management of respiratory care, but the medical quality still was suspected. Therefore, this study discusses what are the significantly related factors of plan or unplan extubation to elevate the quality of respiratory care. PURPOSE The purposes of this study are described bellow¡G 1.To predict the related factors of successful plan extubation. 2.To find the related factors of unplan extubation. 3.To discuss what are the causes of intubation. 4.To find the stand procedure of clinical path-way of ventilator weaning. MATERIAL This study collected data of ICU patient been used ventilator from october 2000 to october 2001. The method of analysis included Descriptive stastic analysis, Correlation, ANOVA, Stepwise regression, and Logistic regression. The data included characteristics of patient, clinical sign, ventilator setting, and the count of intubation days. RESULT 1.The plan extubation of conscious-clear patient is more successful than concious-unclear. 2.The successful extubation of CPPV mode is less than others. 3.Gender is a related factor of unplan extubation. 4.CO2 is postive correction with unplan extubation. 5.PSV mode is negative correction with unplan extubation. 6.CPPV mode is postive correction with unplan extubation. 7.Unplan extubation easily occurs in the early stage of intubation when the patient is unstable.