Thesis (M.Soc.Sc.)--University of Hong Kong, 1993. / Includes bibliographical references. Also available in print.

Thesis (Ph. D.)--Ohio State University, 2006. / Title from first page of PDF file. Includes bibliographical references.

Thesis (M.P.H.)--University of Hong Kong, 2006.

Thesis (M.P.H.)--University of Hong Kong, 2006.

Proefschrift Rijksuniversiteit Limburg, Maastricht. / Met lit. opg. - Met samenvatting in het Nederlands.

No description available.

No description available.

Philosophiae Doctor - PhD / Medicines for human use worldwide are generated in part through the conduct of clinical trials. This is done to ensure safety and efficacy. The involvement of human subjects in drug trials has raised concerns for the protection of human rights. As a consequence of the medical misadventures, the Declaration of Helsinki was formulated in 1964 and revised up to 2002. Today, the International Conference of Harmonization of Good Clinical Practice of 1996 guidelines are used worldwide (including South Africa) in the conduct of clinical trials. This study took place in South Africa. The objectives of the study were to first develop an instrument to be used in identifying the current good clinical practice knowledge and training needs of clinical researchers; secondly identify the knowledge level and training needs using the designed instrument and thirdly, based on the findings, develop a Good Clinical Practice training model so as to facilitate the achievement of quality standards for the conduct of clinical trials in South Africa. / South Africa

Randomization is the key element of any sensible clinical trial. It is the only way we can be sure that the patients have been allocated into the treatment groups without bias and that the treatment groups are almost similar before the start of the trial. The randomization schemes used to allocate patients into the treatment groups play a role in achieving this goal. This study uses SAS simulations to do categorical data analysis and comparison of differences between two main randomization schemes namely unrestricted and restricted randomization in dental studies where there are small samples, i.e. simple randomization and the minimization method respectively. Results show that minimization produces almost equally sized treatment groups, but simple randomization is weak in balancing prognostic factors. Nevertheless, simple randomization can also produce balanced groups even in small samples, by chance. Statistical power is also improved when minimization is used than in simple randomization, but bigger samples might be needed to boost the power.

Magister Pharmaceuticae - MPharm / The World Health Organization estimates that 4 billion people use herbal medicine for some aspect of primary health care. These herbal products are however mostly used without the necessary clinical trial done to prove their pharmacological activities and, therefore, their quality, efficacy and safety. It was the objective of this study to review the current international guidelines for the evaluation of herbal medicine; to gain a perspective on the number, type and quality of clinical trials that have been done on herbal medicine and to adopt a set of guidelines that could be used to conduct trial on a traditional herbal medicine used in South Africa. To verify these guidelines, a protocol for a clinical trial was drafted and submitted for approval to the regulatory and ethical authorities in South Africa. / South Africa