Increasing the efficiency of the methods used through the development and trial of novel pharmaceutical compounds is an important step to reduce the time required to develop new medical treatments. Before a drug can be used, multiple analyses are required to obtain their physical, chemical and biopharmaceutical properties. The aim of this thesis will be to show that SPME can be an advantageous technique in the field of pharmaceutical development due to its use both as a tool to determine the physical properties of drugs and to facilitate clinical development by easily and cheaply providing high-throughput analysis of compounds in biological fluids. It will be demonstrated that a novel coating of triacontyl is capable of rapid equilibrium while providing enhanced sensitivity towards benzodiazepines when compared to shorter chain alkyl extraction phases. The same extraction phase will prove capable of providing a rapid determination of the hydrophobicity of structurally diverse β-blocker drugs while maintaining the use of solvents and analyte to a minimum. We will then show the possibility to produce large quantities of fibers using a robotic apparatus for high-throughput handling of samples. The 96 fiber plate produced will then be used to analyze the target drug loratadine in human plasma using the same apparatus.

Light emitting diodes (LEDs) are generally used in daily life. Our major target is to increase the brightness of LED. We study the package of white phosphor-conversion light emitting diodes (PC-LEDs) and analyze the effect on the luminous flux and color temperature from different locations and concentrations of phosphor coatings and deposition of phosphor. In this study, the color temperature and luminous flux are measured. When the phosphor is placed on the top of the reflected cup with 1.5% of concentration, or on the bottom with 7% of concentration, or when it fills the reflected cup with 1.5% of concentration, the luminous flux is about 40 lm under the CIE 1931 color coordinate of (0.33,0.33). We also studied the effect on deposition of phosphor of two different viscosities of resin used to package white PC-LED. The luminous flux which is packaged with higher viscosity resin is about 12% higher than the one found with the lower viscosity resin. After two hours of deposition, the luminous flux of the white PC-LED which is packaged with the resin of lower viscosity increased 4%, and the one packaged with the resin of higher viscosity increased 7%.

Thesis (Ph. D.)--University of Alberta, 2009. / Title from PDF file main screen (viewed on Nov. 27, 2009). "A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Department of Mechanical Engineering, University of Alberta." Includes bibliographical references.

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Thesis (Ph. D.)--West Virginia University, 2007. / Title from document title page. Document formatted into pages; contains xv, 141 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 132-135).

Thesis (Ph.D.)--Tennessee Technological University, 2006. / Bibliography: leaves 205-206.

Thesis (M.S.)--Rochester Institute of Technology, 1991. / Typescript. Includes bibliographical references (leaves 89-90).

Thesis (Master)--İzmir Institute Of Technology, İzmir, 2006. / Keywords: Biomaterials, biocompatibility, coating, sol-Gel method. Includes bibliographical references (leaves. 110-113).