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Repeated exposure to amphetamine promotes the self-administration of cocaine : sensitization and the contribution of brain dopamine-glutamate interactions /Suto, Nobuyoshi. January 2002 (has links)
Thesis (Ph. D.)--University of Chicago, Dept. of Psychology (Biopsychology), Dec. 2002. / Includes bibliographical references. Also available on the Internet.
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Behavioral mechanisms underlying the extinction of cocaine self-administrationValles, Rodrigo, Jr. 12 April 2006 (has links)
The aim of the present series of experiments was to outline the influence of
different doses of cocaine during training, training schedule, training length and
abstinence duration to modulate subsequent extinction and reinstatement patterns.
Abram AmselÂs general theory of persistence were used to both design and explain
various aspects of these models.
For Experiment 1, rats self-administered cocaine (0.25, 0.50 or 1.00 mg/kg)
intravenously and were then tested in an extinction preparation using saline infusions (5
days) and then only the stimulus light as the reinforcer (3 days). Experiment 2 examined
schedules by magnitude interactions by training rats on two fixed-ratio (FR) schedules
(FR-1 or FR-10 using either 0.25 or 1.00 mg/kg cocaine). Animals were tested in an
extinction protocol (10 days; no stimulus light) and subsequently tested for reinstatement
(1 day) that utilized presentations of the stimulus light. Experiment 3 addressed the
effects of training length (15 or 30 days of training using either 0.25 or 1.00 mg/kg
cocaine) using the same protocol as in Experiment 2. Experiment 4 examined the modulation potential of two abstinence lengths (15 or 30 days using either 0.25 or 0.50
mg/kg cocaine) using the same conditions as Experiment 2.
Experiment 1 indicated the greatest resistance to extinction using the lowest
training dose (0.25 mg/kg). The removal of saline caused an apparent extinction burst
indicative of reward seeking. Experiment 2 showed that animals trained under partial
reinforcement schedules persisted more during extinction. Furthermore, rats trained
using 1.00 were more resistant than those trained with 0.25 mg/kg. Reinstatement of
drug seeking was more pronounced in rats trained using an FR-10 schedule. Experiment
3 indicated greater resistance to extinction in rats trained for 15 versus 30 days. Rats
trained on 0.50 mg/kg for 30 days showed less cue-induced reinstatement than those
trained for 15 days. Experiment 4 showed increased resistance to extinction when rats
were trained on 0.25 mg/kg and forced to abstain for 30 versus 15 days. Directionally
opposite effects were apparent in groups trained with 0.50 mg/kg. Reinstatement data
indicated greater responsivity to cues by animals abstaining for 30 versus 15 days.
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A comparison of cocaine addiction models based on an integration of behavioral, anatomical, and neurochemical studies : a review of proposed mechanisms on why drug addicts stay addicted /Walstrom, Arabella von, January 2008 (has links) (PDF)
Thesis (M.S.) -- Central Connecticut State University, 2008. / Thesis advisor: Mark E. Jackson. "... in partial fulfillment of the requirements for the degree of Master of Science in Biological Sciences." Includes bibliographical references (leaves 34-35). Also available via the World Wide Web.
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Synthesis and pharmacology of site-specific cocaine abuse treatment agentsJavanmard, Sahar 08 1900 (has links)
No description available.
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Glutathione conjugation of a cocaine pyrolysis product AEME and related compoundsMyers, Alan Lewis. January 1900 (has links)
Thesis (Ph. D.)--West Virginia University, 2005. / Title from document title page. Document formatted into pages; contains vii, 138 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 123-134).
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The effects of MDL 72222, Ketanserin and Methysergide pretreatments on cocaine self-administration in rats.Lacosta, Susan, Carleton University. Dissertation. Psychology. January 1992 (has links)
Thesis (M. Sc.)--Carleton University, 1992. / Also available in electronic format on the Internet.
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The periodicity of chronic cocaine self-administration.Fitch, Thomas E. (Thomas Edward), Carleton University. Dissertation. Psychology. January 1992 (has links)
Thesis (M. Sc.)--Carleton University, 1992. / Also available in electronic format on the Internet.
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Detection of drugs of abuse by surface enhanced Raman scattering (SERS)Faulds, Karen Jade January 2004 (has links)
No description available.
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Characterisation of anti-nitrophenylphosphate and anti-tropanyl phenylphosphonate catalytic antibodiesSimms, Caroline Sarah January 1999 (has links)
No description available.
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Mechanisms of AIDS and cocaine related cardiovascular diseaseChaves, Alysia Anne, January 2003 (has links)
Thesis (Ph.D.)--Ohio State University, 2003. / Title from first page of PDF file. Document formatted into pages; contains xx, 401 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: John A. Bauer, Dept.of Pharmacy. Includes bibliographical references (p. 387-391).
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