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The system capacity of the direct-sequence code division multiple access (DS-CDMA) system is limited mainly due to the multiple access interference (MAI), this is basically due to the incomplete orthogonality of spreading codes between different users. In wireless communication environments, the use of DS-CDMA system over multipath channels will introduce the effect of inter-symbol interference (ISI), thus the system performance might degrade, dramatically. To circumvent the above-mentioned problems many adaptive multiuser detectors are proposed, such as the minimum mean square error (MMSE) criteria subject to certain constraints. Unfortunately, with the MMSE receiver it requires an extra training sequence, which decreases the spectral efficiency. To increase the spectral efficiency, the blind adaptive receivers are adopted. In the conventional approach the blind adaptive receiver is developed based on the linear constrained minimum variance (LCMV) criteria, which can be viewed as the constrained version of the minimum output energy (MOE) criteria. Other alternative of designing the blind adaptive receiver is to use the linear constrained constant modulus (LCCM) criteria. In general, the LCCM receiver could achieve better robustness due to the changing environment of channel. With the above-mentioned adaptive linearly constrained multi-user receivers, we are able to reduce the effects of ISI and MAI and achieve desired system performance. However, for worse communication link, the conventional adaptive multi-user detector might not achieve desired performance and suppress interference effectively. In this thesis, we consider a new approach, in which the pre-coder similar to the Orthogonal Frequency Division Multiplexing (OFDM) systems is introduced in the transmitter of the DS-CDMA system. In the receiver, by using the characteristics of pre-coder we could remove the effect of ISI, effectively, and follows by the adaptive multi-user detector to suppress the MAI. Two most common use pre-coders of the OFDM systems are the Cyclic Prefix (CP) or Zero Padding (ZP). Thus the pre-coded DS-CDMA systems associated with the adaptive blind linearly constrained receiver could be employed to further improve the system performance with the cost of decreasing the spectral efficiency.