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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Showing 1 to 2 of 2 (0.041 seconds)

Spelling suggestions: "subject:"colombian A"" "subject:"colombias A""

1

Novel methodology towards the total synthesis of Pseudopterogorgia metabolites

O'Hora, Paul January 2013 (has links)
In 1982, routine screening of the Pseudopterogorgia elizabethae stirred the scientific community by showing the presence of cytotoxic metabolites with antimicrobial activity. Since this discovery a vast amount of research has been conducted in synthesising metabolites of the soft coral. Herein we report the developments towards the synthesis of two metabolites (+)-Erogorgiaene and (+)-Elisabethadione utilising three key reactions in setting up the molecules three chiral centres. The use of asymmetric allylation, oxy-Cope rearrangement and cationic cyclisation was utilised to set up the desired stereocentres from a starting cinnamyl aldehyde. Natural elisabethadione was synthesised in a racemic form as a 2:1 mixture of diastereoisomers at the C-13 stereocentre.
541
2

THE ASYMMETRIC HYDROVINYLATION REACTION: APPLICATIONS IN THE SYNTHESIS OF PSEUDOPTEROGORGIA ELISABETHAE NATURAL PRODUCTS

Cox, Glen Adam 20 June 2012 (has links)
No description available.
Chemistry
Organic Chemistry
hydrovinylation
ethylene
enantioselective synthesis
natural product synthesis
terpenes
pseudopterosins
colombiasin A
elisapterosin B
elisabethin A

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