The purpose of this review of review was to determine if inclusive and comprehensive formal sexual education is effective in promoting safer sex behaviors compared to abstinence only until marriage sexual education, for lesbian, gay, bisexual, transgender and questioning (LGBTQ) adolescents. Peer reviewed articles were retrieved from Cumulative Index to Nursing and Allied Health Literature (CINAHL), Educational Resources Information Center (ERIC), Elton B. Stephens Co. Host (Ebsco Host), Medical Literature On-line (Medline), Psychological Information Database (PsychINFO) and government released statistical information that was published from 2000-2017. Inclusion criteria of synthesized articles were based on formal sexual education aimed at adolescent populations, including focus on LGBTQ subgroups. The literature reviewed demonstrated abstinence only until marriage formal sexual education has minimal to no effects on LGBTQ adolescent’s sexual behaviors. Whereas, comprehensive and inclusive formal sexual education has been shown to increase condom use, delay first sexual interaction, and decrease number of sexual partners and teen pregnancy. In conclusion, the research indicates that individuals who have received comprehensive or inclusive formal sexual education have a greater chance of demonstrating safe sex behaviors compared to those who received abstinence only until marriage sexual education.