Dissertation (Ph.D.)--Auburn University, 2006. / Abstract. Includes bibliographic references.

Diss. (sammanfattning) Stockholm : Karol inst., 2004. / Härtill 5 uppsatser.

Diss. (sammanfattning) Linköping : Linköpings universitet, 2007. / Härtill 4 uppsatser.

Thesis (M.S.)--West Virginia University, 2007. / Title from document title page. Document formatted into pages; contains vii, 36 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 33-36).

Thesis (Ph.D.) - University of Queensland, 2004. / Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin-Madison, 2002. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (p. 240-252).

Class of 2013 Abstract / Specific Aims: To examine the relationship between hospital readmission rates and responses to a medication adherence questionnaire (Morisky) in patients with congestive heart failure (CHF). Methods: The Morisky questionnaire, assessing medication adherence, was administered to all CHF patients admitted from September 15, 2012 to March 7, 2013. Information collected from the electronic medical record (EMR) for all patients with complete Morisky questionnaires included: age, sex, ethnicity, insurance, height, weight, marital status, tobacco use, alcohol use, number of home medications, all-cause and CHF admission in the previous 365 days from when the questionnaire was administered as well as the following events/disease states: myocardial infarction, hypertension, atrial fibrillation, stroke, diabetes mellitus, peripheral vascular disease, chronic obstructive pulmonary disease, congestive heart disease and chronic kidney disease. Main Results: Of the 120 patients enrolled, 52% scored 1-5 on the Morisky questionnaire indicating some problem with medication adherence while 48% scored 0 (no problems). There was no correlation between the Morisky score and age (95% CI: -3.3-5.7), number of medications (95% CI: -0.26, 2.85), or number of comorbidities (95% CI: -1.02,0.03). The Morisky questionnaire was not predictive of all cause readmissions (95% CI: 0.35, 2.01) p = 0.691). For CHF readmissions the Morisky score was not significant (95% CI: 0.6, 4.11, p=0.358) but the confidence interval suggests a trend. Conclusion: There is no correlation between Morisky scores, age, comorbidities, and medication number. Readmission rates were not predicted by Morisky scores; with more participants a trend may be detected for CHF readmissions.

Fatigue and exercise intolerance are common symptoms experienced by patients with chronic heart failure (CHF). Historically it has been argued that central cardiopulmonary factors including pulmonary congestion and reduced lung compliance cause dyspnoea that limits the exercise tolerance of such patients. But recent studies have indicated that exercise capacity in patients with CHF may not be limited solely by central cardiorespiratory factors. Rather the focus has shifted to aspects of the peripheral circulation and skeletal muscle function as possible factors limiting the exercise tolerance of patients with CHF. However there are few studies describing both the structural and functional abnormalities in the skeletal muscle of patients with CHF. In the first study of this dissertation, 11 patients with end-stage heart failure (NYHA class Ill-IV) and 10 healthy control subjects (C) underwent i) graded exercise to exhaustion for determination of peak oxygen consumption (VO₂ peak) and peak work load (Wlpeak); ii) isometric and isokinetic tests of skeletal muscle function and iii) radionuclide angiography for determination of ejection fraction (EF%). VO₂ peak (12.5 ± 1.0 vs 34.3 ± 3.5 mlO₂fkg/min; p<0.001), Wlpeak (73 ± 10 vs 224 ± 14 W; p<0.001), total work performed by the quadriceps muscles (TWQ) in a 30 sec isokinetic test (TWQ; 1565 ± 166 vs 2892 ± 345 J; p<0.05), and hamstring muscles (TWH) (TWH; 604 ± 163 vs 2003 ± 326 J; p<0.05), maximum voluntary isometric contraction (MVC) of the quadriceps muscles (MVC; 134 ± 12 vs 194 ± 11 Nm; p<0.001) and isokinetic peak torque of the ~uadriceps (PKTQ) (PKTQ; 133 ± 15 vs 203 ± 23 Nm; p<0.05) and hamstring muscles (PKTH) (PKTH; 60 ± 8 vs 108 ± 16 Nm; p<0.05) and time to fatigue during a test of isometric endurance (68 ± 12 vs 100 ± 10 sec; p<0.05) were all significantly lower in patients with CHF. However when corrected for the reduced lean thigh volume (muscle mass) in patients with CHF, PKTQ, PKTH and MVC were no longer different from control values. But the total work performed by the quadriceps and hamstring muscles in a 30 second isokinetic test was reduced even when corrected for the reduced lean thigh volume in patients with CHF. Furthermore, patients with CHF terminated progressive cycle exercise to exhaustion at heart rates, rates of ventilation, respiratory exchange ratios and blood lactate concentrations that were significantly lower than values achieved by control subjects during maximal dynamic exercise. These data suggest that skeletal muscle functional abnormalities including a decreased resistance to the development of fatigue exist in patients with severe CHF. In the second study of this dissertation, 10 patients with CHF who participated in the first study and eight control subjects underwent a skeletal muscle biopsy of the vastus lateralis muscle for light and electron microscopic analysis. Significant histological and ultrastructural changes were found in all SM biopsies from patients with CHF. These included atrophy and hypertrophy of fibres, fibre splitting, internalized nuclei, nuclear knots, moth-eaten fibres, increased lipid droplets. Electron microscopy showed a large variety of nonspecific abnormalities, including mitochondrial changes, Z-band degeneration and accumulation of intracellular glycogen. Ultrastructural morphometry revealed capillary basement membrane width significantly increased in the SM of patients with CHF, (409 ± 13 vs 121 ± 3 nm; p<0.01). A novel, blinded, impartially scored method for grading SM pathology showed that SM biopsies of patients with CHF had higher scores for myopathic changes compared to C (12.0 ± 1.5 vs 1.6 ± 1.0 arbitrary units; p<0.05). SM pathology score correlated significantly with VO₂ peak, Wlpeak, and TWQ (p<0.05 to p<0.02) but not with EF%. EF% did not correlate with either VO₂ peak, Wlpeak or TWQ. These data support the hypothesis that: i) severe SM structural and functional abnormalities may limit exercise capacity in patients with CHF; ii) the severity of SM pathology but not resting systolic cardiac function, predicts exercise performance in patients with CHF.

Managing patients diagnosed with congestive heart failure (CHF) requires coordination with subspecialties and frequent outpatient monitoring. The lack of communication among health care providers and patients can result in a gap in practice when managing patients with CHF in the outpatient setting. Guided by the chronic care model, this quality improvement project was an initiative to develop and implement a 6-week self-care management program provided by nurse practitioners in an outpatient primary care practice. The goal of the project was to improve the day-to-day self-care management of patients with CHF and addressed the practice-focused question of whether a 6-week CHF program offered in the outpatient setting would result in better symptom management due to patients' enhanced adherence to treatment plans. A total of 10 patients participated in the 6-week program, and all participants demonstrated improvement in their CHF symptoms, which allowed them to be reclassified into a lower class on the New York Heart Association's CHF staging system. Of the 10 participants, 7 were completely compliant with attending weekly visits, performing daily journaling, and adhering to dietary recommendations and medication management; 3 participants demonstrated less compliance with the self-care recommendations during the program, but also showed sufficient improvement in symptoms to be reclassified. The project demonstrated the potential for reducing the symptom burden of CHF through proactive outpatient management, contributing to positive social change by improving the quality of life for these patients. Nurse practitioners may find the program description helpful for developing similar initiatives in their clinical settings.

Rate of readmission among hospitalized heart failure (HF) patients is used as an indicator of quality and efficiency of healthcare. A low sodium diet is a component of the accepted treatment for HF. Instruction by dietitians may help reduce dietary sodium without negatively affecting quality of life. The effect of low sodium diet education on hospital readmission within 30 and 45 days of discharge for HF patients (N=52) was conducted. Chi-square analysis determined education did not significantly affect remittance within 30 (P=.143) or 45 days (P=.474). Patients readmitted within 30 days were older (P=.005). Men were more likely to be readmitted than women within 30 (P=.021) and 45 days (P=.019). Higher NT-proBNP levels were observed in individuals readmitted within 30 (P=.011) and 45 days (P=.010). Low sodium diet education did not affect readmission but older age, male sex, and higher NT-proBNP values increased the rate of readmission.