nivel de conocimiento de los padres según edad se obtuvo significancia estadistica de p=0.012 y respecto a sexo no se obtuvo significacia estadistica con un p=0,337, el grado de instrucción y ocupación tuvieron significancia estadística en ambos con un p=0.00, la asociacion entre higiene oral de niños y sexo obtuvo significancia estadistica con valor de p=0.006, asi mismo según edad con valor de p=0.042. Se demostró la relación entre el nivel de conocimiento de los padres y la higiene bucal de sus hijos con habilidades diferentes en las tres CEBES de la región Lambayeque. / The objective of the study was to determine the relationship between the level of knowledge of parents about oral health and the oral hygiene index of their children with different abilities in Lambayeque, 2023. The study was analytical, cross-sectional, observational and correlational. A total of 150 students and their parents from three Special Basic Education Centers in Lambayeque participated. A validated questionnaire was used on the parents and a clinical examination was performed on the children applying the simplified oral hygiene index, the data were recorded in an Excel database. The data were analyzed using the Chi-Square test. Statistical significance was obtained between the level of knowledge of parents about oral health and the oral hygiene index with a value of p=0.00, regarding the association between the level of knowledge of parents according to age, statistical significance was obtained with p=0.012 and regarding sex, no statistical significance was obtained with p=0.012 and with respect to sex, statistical significance was not obtained with a p=0.337, the degree of education and occupation had statistical significance in both with a p=0.00, the association between oral hygiene of children and sex obtained statistical significance with a value of p=0.006, likewise according to age with a value of p= 0.042. The relationship between the level of knowledge of parents and the oral hygiene of their children with different abilities is demonstrated in the three CEBES of the Lambayeque region.