The prevalence of tobacco use among blue-collar workers such as construction artisans is disproportionately higher than in the general population, yet very limited studies have been conducted about such workers in Nigeria, the most populous country in sub-Sahara African (SSA). Therefore, this study aims to assess the prevalence and the associated risk factors of tobacco use among construction artisans in Ekiti State, Nigeria. This cross-sectional study employed a multi-stage stratified sampling technique to select participants (carpenters and bricklayers) artisans, journeymen, and their apprentices who were working in Ekiti State. Chi-square and logistic regression were conducted to delineate factors that are associated with tobacco use in this population. The results show that the prevalence of ever-smoke amongst respondents was 19.3%, and multivariate analysis showed that artisans who were within the age range 31-40 years were four times more likely to use tobacco (aOR=3.410; CI=1.476-7.878), compared with those that are less than 20 years. Additionally, being in school (aOR 2.007; CI= 1.026-3.927) and divorced/separated (aOR4.240; CI=1.307-13.759) were associated with tobacco use, compared with the respective populations. The increased prevalence of tobacco use among construction artisans is noteworthy, and few self-reported cases of addiction amongst users demand action from communities and government at all levels. There is need to improved access of artisans to accurate information and tailored messages on dangers of tobacco use. Moreover, smoking and worksite regulations and policies would be needed to curtail the smoking tendencies of these workers