We continue to build support for the proposal to use H II galaxies (HIIGx) and giant extragalactic H II regions (GEHR) as standard candles to construct the Hubble diagram at redshifts beyond the current reach of Type Ia supernovae. Using a sample of 25 high-redshift HIIGx, 107 local HIIGx, and 24 GEHR, we confirm that the correlation between the emission -line luminosity and ionized -gas velocity dispersion is a viable luminosity indicator, and use it to test and compare the standard model Lambda CDM and the R-h = ct universe by optimizing the parameters in each cosmology using a maximization of the likelihood function. For the flat Lambda CDM model, the best fit is obtained with Omega(m) = 0.40(-0.09)(+0.09). However, statistical tools, such as the Akaike (AIC), Kullback (KIC) and Bayes (BIC) Information Criteria favour R-h = Ct over the standard model with a likelihood of approximate to 94.8-98.8 per cent versus only per cent. For wCDM (the version of ACDM with a dark -energy equation of state wde = Pde/Pde rather than was t WA = 1), a statistically acceptable fit is realized with Omega(m) = 0.221(-0.14)(+0.16) and wde = 0.511'0'21-5" which, however, are not fully consistent with their concordance values. In this case, wCDM has two more free parameters than R-h = Ct, and is penalized more heavily by these criteria. We find that R-h = Ct is strongly favoured over wCDM with a likelihood of approximate to 92.9-99.6 per cent versus only 0.4-7.1 per cent. The current HIIGx sample is already large enough for the BIC to rule out ACDM/wCDM in favour of R-h = Ct at a confidence level approaching 3 sigma.