Thermal Barrier Coating systems (TBCs) serve as a key component in gas turbines in aerospace engines, isolating the metallic substrate from severe heat flux of the environment. The durability of TBCs has been considered to be a critical issue to determine the service lifespan of hot section components. Comprehensive studies of failure mechanisms benefit the gas turbine industry to develop TBCs with better material properties and stable microstructures, thus potentially enhancing their durability. To date, many failure mechanism analyses have been conducted based on the understanding of critical residual stress developed under different thermal tests. For the present study, using the Finite Element (FE) method with temperature-process-dependent model parameters, the maximum residual stress is calculated with evolution of the localized/global interfacial roughness profile based on Electron Beam-Physical Vapour Deposition Thermal Barrier Coating system (EB-PVD TBCs). With studies of cracking routes from past research, qualitative failure mechanism analysis is conducted for EB-PVD TBCs. In addition, the estimated energy release rates are compared to reveal the effect of different thermal profiles on the crack driving forces for Atmospheric Plasma Sprayed Thermal Barrier Coating systems (APS-TBCs). Using previously observed cracking routes from different thermal cycling experiments, a quantitative failure mechanism analysis is conducted for APS-TBCs with modified analytical expressions. In addition, literature works revealed that physics and mechanics-based models were proposed to evaluate environment induced damage. For the last part of my research, erosion of EB-PVD TBCs is estimated using a modified solid particle erosion model. A stochastic approach is applied to study the erosion of EB-PVD topcoat (TC) under real engine service conditions. The durability of TBCs is affected by both oxidation-induced degradation and environment-induced damage. The combination of “internal” crack driving forces (generated from residual stresses developed upon different stages of thermal cycles) and “external” erosion damage (from temperature-process dependent brittle/ductile erosion) lead to complexity of evaluating durability under different service conditions.