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Inquiry of Lipid Membranes Interacting with Functional Peptides and Polyphenol Drug MoleculesHo, Chian Sing 24 June 2016 (has links)
Cellular membranes are important targets for many membrane-active peptides and drug compounds. Here we are interested in deciphering how lipid membranes are perturbed by several membrane-active molecules, including the transmembrane domain of the influenza M2 protein (M2TM), aggregates formed by a synthetic polyglutamine peptide, and three polyphenol compounds (i.e., tamoxifen, genistein, and verapamil). We employ phase-separated ternary lipid model membranes in the form of giant unilamellar vesicles (GUVs) to simulate raft-like structures that have been proposed to govern many important processes in plasma membranes (e.g., intracellular singling and trafficking). Specifically, we use fluorescent microscopy to interrogate how those membrane additives modulate the phase behavior of free-standing GUVs, as well as the miscibility transition temperature (Tm). We find that M2TM increases Tm and causes vesicle budding; polyglutamine aggregates disrupt lipid membranes; and the three polyphenol compounds exert disparate effects on GUV Tm.
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Topology and Strong correlation effect of Hidden symmetry breaking superconductor / 隠れた対称性の破れを伴う超伝導体におけるトポロジーと強相関効果Nogaki, Kosuke 25 March 2024 (has links)
付記する学位プログラム名: 京都大学卓越大学院プログラム「先端光・電子デバイス創成学」 / 京都大学 / 新制・課程博士 / 博士(理学) / 甲第25103号 / 理博第5010号 / 京都大学大学院理学研究科物理学・宇宙物理学専攻 / (主査)教授 柳瀬 陽一, 教授 石田 憲二, 准教授 北川 俊作 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DGAM
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