Driven by the ambition for ubiquitous networking, wireless networks had gained substantial technical advances in recent years. Using radio signals in air as data links, wireless networks can get rid of the tangling of wired cables. However, due to the inherent limitations of wireless channels and legacy protocol design, users of wireless networks today still suffer from the problems on low bandwidth and high error rates. The seven-layer Open System Interconnection (OSI) model was originally designed with wired network environments in mind. Following the seven-layer OSI model, each layer is responsible for handling specific tasks without communicating with each other. Due to the relative stability of wired channels, the strictly-layered approach works well in wired network environments. However, its adequacy is a controversy in wireless environments, since wireless networks have completely different characteristics from its wired counterparts. In wireless environments, channel conditions are highly time-varying and are affected by many factors. External interference or signal degradation may lead to severe packet loss. Even signal-to-noise ratios are fine, transmissions may still fail due to collisions when contention-based MAC protocols are adopted. Conventional protocols developed with wired network environments in mind cannot appropriately response to the characteristics of wireless channels and may make wrong reactions. For these reasons, a flexible framework to capture the rapid change conditions of wireless channels and respond to them immediately is necessary. In this dissertation, we design a cross-layer framework with the consideration of wireless network characteristics. By the coordination between the involved layers, the cross-layer framework can adapt to wireless channel conditions and significantly improve QoS in wireless networks. In order to reduce collision probabilities in wireless networks, we propose a novel protocol named Wait-and-Transmit, which effectively alleviates contentions in wireless networks. By reducing collision probabilities of wireless networks, transmission delays can be shortened and throughputs can be significantly improved. Aiming at the transmission paths containing at least one wireless link, a flexible and efficient cross-layer transmission scheme is also present in this dissertation, which separates the rapid change conditions such as collision probabilities from the relatively stable conditions and well responds to these changes. The proposed approaches significantly improve the performance of wireless networks. We believe that these approaches can contribute to the development of wireless networking.