After the opening and reform in 1978, Mainland China has undergone economic development for 30 years and is currently the fourth largest economic body in the world. Taiwan, on the other hand, has not been able to response actively and began industrial distribution when faced with the impact of the rise of China. Taiwan adopted a closed-door policy that caused the migration of industries and resulted in hollowing-out and marginalization. This phenomenon is particularly serious in Kaohsiung that is dominated by traditional industry that caused steady high unemployment rates. After the new government took office, the interactions between the straits became frequent, and that created a valuable development opportunity for Kaohsiung. This study takes the integrated framework for public affairs management to analyze the difficulties encountered in the development of Kaohsiung. With ¡§Strategy of Cross-Strait Harbor City Cooperation to Promote Talent Development in Kaohsiung in Response to Direct Flight ¡¨ as the research topic, this study utilizes interactive management (IM) to conduct rational debates from various perspectives. After two discussions, 12 strategies were concluded and their implementation order has been conducted through interpretative structural mode (ISM). The strategies are as follows: The Kaohsiung City Government shall: 1. Establish the ¡§Mainland China Affairs Office¡¨ to be responsible for talents in China to study or work in Taiwan; 2. Amend or establish relevant laws and regulations on the cross-strait exchange; 3. Consolidate the investment of private business to improve the performance of school in order to cultivate local talents through school performance while recruiting talents from China; 4. Lift laws and regulations to utilize public manpower and organization flexibly; The schools shall: 5. Establish departments and research projects regarding harbor city development; 6. Recruit internationally renowned scholars to conduct short-term courses in higher education; 7. Organize relevant workshops for teachers to understand the background and policy of cultural exchange across the straits; The government and the private sector may: 8. Establish a certification mechanism to recognize degrees across the straits; 9. Plan and establish a perfect science park; 10. Include professionals from China into the scope of the current foreign workers for special professions or technical assignments; 11. Provide attractive incentives to attract professionals and students from China to Kaohsiung; To accomplish the goal: 12. Provide attractive incentives to attract business to establish operational headquarters in Kaohsiung in order to promote the development of Kaohsiung. This study also examines 1. The view on establishing offices in Kaohsiung and the major cities in China such as Shanghai, Beijing, Guangzhou, etc. to reinforce the marketing of cities and conduct cross-strait harbor city cooperation; 2. How the Kaohsiung City Government attracts tourists from China; and 3. How the Kaohsiung City Government shall prepare to respond to the opening of the cross-strait relations. Through expert interviews, this study aims to provide substantial and feasible strategic recommendations.