This research compares the energy performance of a code-built residential building within the moist climate zone classification in Canada, Europe, and the Northeastern United States. The primary objectives are to reveal how specific differences in code requirements in similar climates influence a building’s energy profile, offer a means to quantify and evaluate the extent of energy savings as a result of each requirement, and provide a comparison of each location’s building culture and how this affects the standards in place. Using the building energy simulation tool, DesignBuilder EnergyPlus Simulation, a model single-family home was created and input energy code requirements for each location. An evaluation of each location’s building culture is examined through such factors as the training of building professionals, commonly used materials and products, energy reduction goals, and cultural attitudes. The results of this study point to the need for more advanced building practices, stricter code mandates, and higher performing products based on energy savings achieved from buildings built to different standards in equivalent climate zones. This has the potential to drive the development and use of better performing building materials and assemblies in the future.