<p><strong>Introduction: </strong>Barefoot running is growing in popularity as runners seek strategies to avoid running-related injuries (RRIs). A new theoretical perspective suggests that the improved cutaneous sensation during barefoot running results in a less injurious running style characterized by increased cadence, landing on the forefoot and more knee flexion. The mechanisms by which the barefoot running style may have an effect on RRIs are not well understood.</p> <p><strong>Purpose: </strong>Explore the new theoretical perspective on RRIs that supports the barefoot running style and investigate the effects of modified cutaneous sensation on the adaptation to and retention of the barefoot running style.</p> <p><strong>Methods: </strong>First, a scoping review was performed to identify implicit theory underlying both traditional shod and barefoot running research and practice. Second, a feasibility study investigated altered cutaneous sensation as a proposed mechanism by which a person learns and retains the skill of barefoot running. Sixteen participants ran shod on a treadmill then were randomized to receive one of four cutaneous sensation treatments. They then ran barefoot for the first time and 48 hours later. Changes in the cadences, foot angles and knee angles means and variations across runs and treatment groups were used to quantify learning and retention.</p> <p><strong>Results:</strong> The scoping review provided evidence that improved plantar cutaneous sensation, such as when one runs barefoot, could reduce the risk of RRIs. In the feasibility study, our findings suggest that barefoot compared to shod running increased plantar cutaneous sensory thresholds, and increased mean cadence and mean foot angle. Improved retention of the barefoot running style was shown in the treatment group with anaesthetic cream on their legs.</p> <p><strong>Conclusions: </strong>Plantar cutaneous sensation is proposed as an important factor when exploring the etiology of RRIs. This knowledge may influence an individual’s risk of experiencing a running-related injury.</p> / Master of Science Rehabilitation Science (MSc)