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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 2 of 2 (0.083 seconds)Spelling suggestions: "subject:"cytotoxicity lymphocites"" "subject:"cytotoxicity lymphocytes""
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Periodic solutions and bistability in a model for cytotoxic T-lymphocyte (CTL) response to human T-cell lymphotropic virus type I (HTLV-I)Lang, John Cameron 11 1900 (has links)
HTLV-I is the first discovered human retrovirus and a causative agent of both adult T-cell leukemia (ATL) and HTLV-I-associated myelopathy (or tropical spastic paraparesis) (HAM/TSP). Previous models have been successful in providing insight into the progression of HTLV-I infection. The relative simplicity of HTLV as well as its similarities to HIV and other diseases allow HTLV-I research to have diverse applications.
The development of HAM/TSP is precipitated by a CTL immune response. Previous models for CTL response to HTLV-I infection have had relatively simple behaviours. A novel sigmoidal CTL response function results in complex behaviours previously unobserved. We establish the existence of bistability between solutions corresponding to carrier and endemic states. In addition, both super- and sub-critical Hopf bifurcations as well as the resulting stable and unstable periodic solutions are observed. Analytical and numerical results are discussed, as well as the biological consequences of the aforementioned behaviours. / Applied Mathematics
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Periodic solutions and bistability in a model for cytotoxic T-lymphocyte (CTL) response to human T-cell lymphotropic virus type I (HTLV-I)Lang, John Cameron Unknown Date
No description available.
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